Scientific computing is marked by applications with very high performance demands. As technology has improved, reconfigurable hardware has become a viable platform to provide application acceleration, even for floating-point-intensive scientific applications. Now, reconfigurable computers-computers with general purpose microprocessors, reconfigurable hardware, memory, and high performance interconnect-are emerging as platforms that allow complete applications to be partitioned into parts that execute in software and parts that are accelerated in hardware. In this paper, we study molecular dynamics simulation. Specifically, we study the use of the smooth particle mesh Ewald technique in a molecular dynamics simulation program that takes advantage of the hardware acceleration capabilities of a reconfigurable computer. We demonstrate a 2.7-2.9× speed-up over the corresponding software-only simulation program. Along the way, we note design issues and techniques related to the use of reconfigurable computers for scientific computing in general.

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Objective:The present study aimed to investigate the probable differences in cell proliferation index of odontogenic cysts and tumors by means of a comparative silver stained nucleolar organizing region (AgNOR) quantification.Study Design:This descriptive cross-sectional study was done on archival paraffin blocks (n = 62), consisting of 10 odontogenic keratocysts, 10 dentigerous cysts, 10 radicular cysts, 10 conventional ameloblastomas, 10 adenomatoid odontogenic tumors, 10 calcifying epithelial odontogenic tumors and 2 ameloblasic carcinomas.Results:The mean AgNOR count of odontogenic cysts was 1.709 and the benign odontogenic tumors was 1.862. Highest AgNOR count was recorded in odontogenic keratocyst and lowest was seen in radicular cyst. Statistically significant difference in AgNOR counts of ameloblastoma and adenomatoid odontogenic tumor, amelobalastoma and calcifying epithelial odontogenic tumor, benign odontogenic tumors and ameloblastic carcinoma were seen. AgNORs in ameloblastic carcinoma were more in number and more widely spread.Conclusion:AgNOR technique may be considered a good indicator of cell proliferation in odontogenic cysts and tumors.