An integration of two dynamic research paradigms- organocatalysis and remote C-H bond functionalization has together emerged as a profound competition to the conventional transition-metal catalyzed processes. In the contemporary research...
An effective organocatalyst, ascorbic acid has been successfully applied for the ipso-hydroxylation of arylboronic acid using 30% aqueous H 2 O 2 as oxidant in water at ambient temperature. The methodology proceeds without using any metal catalyst or base and avoids harsh reaction conditions. The protocol is applicable to various electronically diverse arylboronic acid moieties with good to excellent yield.
Iodine-catalyzed selective C-3 benzylation
of indoles with benzylic
alcohols is developed. The reaction proceeds with molecular iodine
as the catalyst under ligand-, metal-, and base-free conditions and tolerates wide functionalities. The
experimental observations account for the halogen-bond activation
mechanistic pathway for the molecular iodine catalysis.
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