Background We sought to determine the association between appendicular adiposity and hypertension, with the purpose of better understanding the role of body fat distribution on blood pressure (BP). Methods We included 7411 adults aged 20 to 59 who were not taking antihypertensives and without cardiovascular disease from the 2011 to 2018 National Health and Nutrition Examination Surveys. Leg & arm adiposity, determined via dual-energy X-ray absorptiometry scans, was defined as percent of total body fat present in legs/arms (leg/total%, arm/total%). Measures were categorized into sex-specific tertiles. We estimated change in BP and odds ratios (ORs) of hypertension (BP ≥ 130/80) and hypertension subtypes using multivariable, survey design-adjusted linear & logistic regression, respectively. Results Of the participants, 49% were female, the average (standard deviation) age was 37.4 (0.3) years, and 24% had hypertension. Those in the highest tertile (T3) of leg/total% had 30% decreased adjusted ORs (aOR) of hypertension compared to the lowest tertile (T1; aOR, 0.70; 95% confidence interval [95% CI], 0.55–0.89). This association was not significant for arm/total% (0.89, 0.68–1.17). T3 of leg/total% was associated with 49% lower, 41% lower, and unchanged relative odds of isolated diastolic hypertension (IDH), systolic-diastolic hypertension (SDH), and isolated systolic hypertension (ISH) compared to T1 (IDH: 0.51, 0.37–0.70; SDH: 0.59, 0.43–0.80; ISH: 1.06, 0.70–1.59). For every 10% increase in leg/total%, diastolic BP decreased by an adjusted mean 3.5 mmHg (95% CI, − 4.8 to − 2.2) in males and 1.8 mmHg (95% CI, − 2.8 to − 0.8) in females (P < 0.001 for both). Conclusions A greater proportional distribution of fat around the legs is inversely, independently associated with hypertension, and more specifically, diastolic hypertension (IDH and SDH).
The purpose of this cross-sectional, exploratory analysis was to describe age-related patterns of blood pressure (BP) among participants in India (using the 2014 Annual Health Survey) and the United States (using National Health & Nutrition Examination Surveys 2011-2016). We included 10,759 U.S. and 790,641 Indian participants aged ≥20 years with ≥2 BP readings. We plotted mean systolic (SBP) and diastolic BP (DBP) across 5-year age groups and estimated best fit models. SBP increased linearly with age in both sexes and study populations (R 2 : 0.88-0.99; Fig. 1-2). Those with overweight/obese BMI had higher SBP and modestly higher rates of increase in SBP. DBP followed a quadratic curve (R 2 : 0.68-0.99), peaking in the 5-6th decade (45-49 years in U.S. and 50-59 in India) with higher and earlier peaks in those with elevated BMI. The models’ strong fit and similarity between study populations supports the notion that physical processes underly BP’s age-related changes.
10606 Background: Weight gain after the diagnosis of BC has been associated with increased risk of recurrence and mortality. Previous studies have documented weight gain after cyclophosphamide, methotrexate, and 5-fluoruracil (CMF) and adriamycin and cyclophosphamide (AC) chemotherapy, but the impact of taxane chemotherapy has not been described. Methods: We reviewed the charts of 119 patients (pts) who completed neoadjuvant Ctx between 1997–2005. Age, baseline body mass index (BMI), tumor size, nodal status, hormone receptor status, menopausal status, co-morbid illnesses and anti-depressant use were collected. Weight was recorded at each Ctx visit and at follow-up visits for two years. Results: 22 pts received AC only. 97 pts received AC followed by a taxane - 58 docetaxel (D), 39 paclitaxel (P). Median f/u time was 26.3 months. 66/119 (55%) of pts gained weight during Ctx, with a median change of + 1 pound (range -28 to +19.5 pounds) at the end of Ctx. 49/119 (41%) of pts gained weight during AC and 76/97 (78%) of pts gained weight during the taxane. Mean weight change after AC was -1.8 pounds compared to +3.2 pounds after the taxane (p < 0.001). Age, baseline BMI, and menopausal status prior to Ctx did not predict weight gain. There was no difference in weight gain between pts who received D vs. P (p = 0.19). 8/22 (36%) patients who received AC alone recurred, and 13/95 (14%) who received both AC and T recurred; however this was not statistically significant (p = 0.23). Total weight change during neoadjuvant Ctx did not predict recurrence; however weight gain during the AC portion was associated with a higher risk of recurrence when adjusted for weight gain during taxane Ctx (p = 0.035, Cox regression). Each one pound gained was associated with an 11% increase in risk of recurrence. Conclusions: Weight gain is common during neoadjuvant Ctx for BC, particulary during treatment with taxanes. Further follow up is required to establish if weight gain is maintained over time and to determine the impact of weight change on BC outcomes and health. No significant financial relationships to disclose.
Objective: We sought to determine whether leg adiposity was inversely associated with hypertension using the 2011-2016 National Health & Nutrition Examination Surveys. Methods: The study included 5,997 non-pregnant adults aged 20-59 who were not taking antihypertensives and did not have self-reported history of cardiovascular disease. Leg adiposity was defined as the percent of total fat mass present in bilateral lower extremities as per dual-energy x-ray absorptiometry (DXA) scans. Leg adiposity was then categorized into two sex-specific groups (low fat %: <34 for male, <39 for female; high fat %: ≥34 for male, ≥39 for female). The outcome was hypertension subtype. Hypertension was defined as BP >130/80, and subtypes included isolated diastolic hypertension (IDH), isolated systolic hypertension (ISH), and systo-diastolic hypertension (SDH). We estimated relative risk ratios (RRR) using multinomial logistic regression, adjusting for covariates (see Table 1 ) and accounting for the complex survey design. Results: Among the 5,997 participants, 2,945 (49%) were female, the average (SD) age was 37.4 (0.3) years, and 1,465 (24%) had hypertension. Those with higher leg fat had 53%, 39%, and 61% lower unadjusted relative odds of IDH, ISH, and SDH, respectively ( Table 1 ). After adjustment, those with higher leg fat had 31%, 24%, and 34% lower relative odds of IDH, ISH, and SDH, respectively. When treating leg adiposity as a continuous variable, higher leg adiposity reduced relative odds of SDH significantly more than ISH ( Table 1 ). Conclusion: A greater proportional distribution of fat around the legs is inversely, independently associated with all hypertension subtypes.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.