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Rosai–Dorfman disease (RDD) is a benign histioproliferative disorder characterized by generalized lymphadenopathy, weakness, anemia, and rarely extranodal involvement. The disease affects the central nervous system (CNS) very rarely and at a relatively older age. Isolated intracranial involvement is very rare. RDD tends to present as dural masses mimicking meningioma, though very rare case reports describe isolated parenchymal involvement in the CNS. Only one case of intraventricular RDD has been described so far to the best of our knowledge. We present a very rare presentation of this disease as an isolated intraventricular presentation in the region of the atria of the lateral ventricles.

The patient, 22 year old, married since 3 years presented with history of primary infertility and excessive hair growth with change in the voice. She had history of oligomenorrhea and noted decrease in the size of the breast. There was no other significant past medical or surgical history. On general examination, vital parameters were within normal limits. Hirsutism was present. Genital examination revealed the presence of Clitoromegaly. Laboratory investigations revealed S. Androstenedione levels of more than 10ng/ml (Range: 0.3-2 ng/ml) and the level of S. Testosterone was 6.79 ng/ml (Range: 0.15-0.7 ng/ml). S. FSH level was 6.8 miu/ml (Range: 2.3-18.5 miu/ ml), S. LH level was 7.95 miu/ml (Range: 0.4-105 miu/ml) while S. ACTH level was 21.2 pg/ml (Range: 5-27 pg/ml). MRI Pelvis revealed right ovary measuring 4.6 X 4.4 X 3.4 cm which showed a focal lesion in the ovarian stroma. The left ovary was normal. Patient underwent right salpingooophorectomy with left ovarian drilling. Pranav Pramod Patwardhan*, Annapurna Chandrashekhar Taware and Pragati Aditya SatheDepartment of Pathology, Seth G S Medical College, Mumbai, India ABSTRACTSex cord stromal cell tumours constitute 5-8 % of all ovarian neoplasms. Steroid cell tumours are a type of sex cord stromal cell tumours. The name "Steroid cell" stands for the morphology and the functionality of these tumours. Steroid cell tumours-Not otherwise specified constitute about 56% of all steroid cell tumours and presents more commonly with androgenic manifestations in third to fourth decade.We present a case, 22 year old, who presented with virilizing symptoms. MRI was suggestive of an right ovarian mass for which right salpingo-oophorectomy was done. Histopathology revealed features classical of Steroid cell tumour-Not otherwise specified. We present the case for a relatively younger age at presentation and the classical histomorphology.

A 70-year-old female, post menopausal since 28 years and married since 45 years, came with complaints of a growth protruding through the vagina. She had no history of difficulty in micturition, burning micturition, previous allergy, previous blood transfusion or intake of hormone replacement therapy drugs. On general examination, vital parameters were within normal limits. On per speculum examination cervical erosion and third degree uterovaginal descent with cystocele and a rectocele was noted. Vagina was healthy on examination. Uterus was atrophic on per vaginal examination. Investigations revealed haemoglobin of 9.1 gm/dl, total WBC count of 5600/ mm 3 and platelet count of 2.73 lacs/mm 3 . Serum Cholesterol levels were normal (185 mg%) while serum triglyceride levels were raised (274mg%).A vaginal hysterectomy with abdominoperineal repair was done and hysterectomy specimen was sent for histopathological examination. AbSTRACTAlthough lipomas are very common tumours, pure uterine lipomas are extremely rare. Their reported incidence is 0.03-0.2%. They commonly present with symptoms similar to that due to leiomyoma except that they occur in post menopausal elderly females. We report a case of 70-year-old elderly female, who presented with third degree uterovaginal descent. A total vaginal hysterectomy was done for her. The hysterectomy specimen showed presence of a well circumscribed uterine fundal lipoma. We report this case because of its rare occurrence in the uterine fundus. Gross and MicroscopyA simple hysterectomy specimen measuring 9 X 4 X 1.5 cm was received. The corpus measured 4.5 X 4 X 1.5 cm while cervix measured 4.5 X 4 X 1.5 cm. On cutting, a well circumscribed, encapsulated yellowish mass measuring 2.5 X 2 X 1.4 cm was identified along the uterine fundus b]. A slit like endometrial cavity was noted. The endometrial thickness was 0.1 cm while the myometrial thickness was 0.9 cm. Ectocervix was epidermidized while endocervix was unremarkable.Microscopy revealed a well encapsulated tumour composed of mature adipocytes arranged in lobules separated by thin fibrovascular septae. The tumour was surrounded by rim of myometrial muscle [Table/ Fig-1c-f]. Endometrium showed cystic atrophy while cervix showed changes of chronic cervicitis with squamous metaplasia. No leiomyoma was identified.Immunohistochemistry (IHC) revealed positivity of the adipocytes for S-100 while they were negative for Desmin and SMA. The patient was discharged as she was stable postoperatively and was not having any new complaints on follow up examination. Most women who were diagnosed to have uterine lipomas belonged to the postmenopausal age group [2]. These lesions can be asymptomatic at presentation and may be incidentally diagnosed or can more commonly present with symptoms like that of a leiomyoma which include abdominal pain and vaginal bleeding [3]. Radiologically, the lesions may be missed and only MRI could be valuable in detecting the fat content of the tumour [4]. These tumours commonly measure 5-10 cm in size and are f...

Objective Independent assessment of SARS-CoV-2 antigen (COV2Ag) tests remains important as varying performance between assays is common. We assessed the performance of a new high-throughput COV2Ag test compared to SARS-CoV-2 nucleic acid amplification tests (NAAT). Methods A total of 347 nasopharyngeal samples collected from January to October 2021 were assessed by NAAT as part of standard-of-care testing (CDC LDT or GeneXpert System, Cepheid) and COV2Ag using the ADVIA Centaur CoV2Ag assay (Siemens Healthineers). Results Among NAAT positive specimens we found 82.4% agreement and in NAAT negative specimens we found 97.3% agreement (overall agreement 85.6%). In symptomatic persons, COV2Ag agreed with NAAT 90.0% (n = 291), and in asymptomatic persons, 62.5% (n = 56). Agreement between positive NAAT and COV2Ag increased at lower cycle threshold (Ct) values. Conclusion The COV2Ag assay exceeded the World Health Organization minimum performance requirements of ≥ 80% sensitivity and ≥ 97% specificity. The COV2Ag assay is helpful for large scale screening efforts due to high-throughput and reduced wait times.

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Sex cord stromal cell tumours constitute 5-8% of all ovarian neoplasms of which pure leydig cell tumours constitute 0.1%. These tumours are most commonly found in the post-menopausal age group and patients present with a rapid onset of symptoms of androgen excess like hoarseness of voice, clitoromegaly and hirsutism. We present a case of 39 year old female, who presented with virilising symptoms since 2 years. Serum Testosterone levels were raised and CT revealed homogeneously enhancing mass of 2.8 cm in size in the right ovary. An unilateral oophorectomy was done and sent for histopathological examination. On Gross examination, the ovary revealed the presence of a well circumscribed greyish white tumour with multiple yellowish areas. Microscopy revealed features suggestive of pure leydig cell tumour with reinke crystals. Post operatively, the patient improved symptomatically. The unusual features seen in this case were younger age at presentation and insidious onset of symptoms. The presentation of pure leydig cell tumour-hilar type at such a young age is extremely uncommon.