Background. Bronchopleural fistulas (BPFs) development after pneumo nectomy remains a serious complication and is associated with high mortality rate. We evaluated incidence and risk factors, that influenced BPF rate after pneumonectomies for lung cancer patients treated at the Department of Thoracic Surgery and Oncology of the Institute of Oncology, Vilnius University, and compared different bronchial stump suturing techniques. Methods. It is a retrospective study. We reviewed 580 lung cancer patients who underwent pneumonectomies from January 1990 to January 2009. The average patient's age was 60.1 ± 7.9 years (range from 34 to 76). Patients according to postoperative staging: stage IIA-30 patients, IIB-80, IIIA-320, IIIB-96, IV-54. The most common tumor histology was planocellular carcinoma-301, adenocarcinoma-108, small-cell carcinoma-76. Results. There were 327 (56.4%) right and 253 (43.6%) left pneumonectomies. Mediastinal lymph node dissection (LND) was performed to 387 (66.7%) and lymph node sampling (LNS) to 193 (33.3%) patients. The bronchial stump was covered in 285 (49.1%) patients. Bronchopleural fistula after pneumonectomy developed in 48 (8.3%) patients (bronchial dehiscence was confirmed by bronchoscopy), and 7 patients with BPF died (14.5%). BPF after right pneumonectomy occurred in 30 cases (9.5%) and after left pneumonectomy in 18 cases (7.1%), the difference was not statistically significant (p > 0.05). BPF after LND occurred in 38 cases (9.82%) and after LNS in 10 cases (5.18%), the diff erence was statistically significant (p < 0.05). BPF rate using suturing devices with changeable staples (UKL-40, UKL-60, UO-40, UO-60) was 12.6%, using me chanical staplers and handmade suture it was 4.1% and 8.8%, respectively. The difference between the groups was statistically significant (p = 0.0071). Conclusions. 1. BPF rate after pneumonectomies for lung cancer patients was lowest using mechanical staplers (4.1%). 2. BPF occurrence rate after right and left pneumonectomy had no statistically significant difference. 3. BPF rate after pneumonectomy was higher in the LND group (9.82%) than in the LNS group (5.18%), the difference was statistically significant (p < 0.05).
S594ate dose constraints are applied to the clinical target volume (CTV), planning target volume (PTV), contralateral lung, heart, spinal cord, esophagus, liver and kidneys. Beam geometry consisted of 8 nonoverlapping coplanar beams (mixed 6/10 MV photons). The PTV was prescribed 50 Gy in 25 daily fractions over 5 weeks. Bolus was applied over the scar to ensure adequate skin dose. The plan was optimized in the partially filled TC case. A density override was applied to the TC to simulate the completely filled TC (1 g/cm 3 ) and completely empty (0 g/cm 3 ) cases, assuming identically treated plans (same monitor units). The doses to the regions of interest were compared. Results: Comparing the empty, partially filled and full TC cases respectively, we find:
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