Indole derivatives are best known for their biological importance as bactericides and fungicides which encouraged us to synthesize some Schiff bases of substituted indoles i.e. 2( ([1,3,4]thiadiazino [6,5-b]indol-3-ylimino)methyl)substituted phenols. The synthesized compounds are found to exhibit antitubercular activities. With a view to enhance solubility induced potential anti tubercular activities, these synthesized compounds are encapsulated with β-cyclodextrin. Through elemental and spectral (UV, IR, 1 H NMR) characterization, the architecture of the compounds and their inclusion complexes are confirmed. They are also screened for in vitro antitubercular activities by using rifampicin as the reference standard. The synthesized compounds exhibited good antitubercular activity but their inclusion complexes exhibited profound antitubercular activities as compared to their respective compounds.
Schiff bases having indole moiety are well known biological active agents. The present researchdeals with the preparation of 5-substituted furan-2-yl) [1,3,4] thiadiazino [6,5b]indole-3-amine from 2-amino 1,3,4-thiadiazino[6,5b]
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