Kaposi's sarcoma-associated herpesvirus (KSHV) infection of in vitro target

Human herpesvirus 8 (HHV-8

Kaposi's sarcoma-associated herpesvirus (KSHV) in vitro targetKaposi's sarcoma-associated herpesvirus (KSHV), a member of the lymphotropic human gamma-2 herpesvirus family (genus Rhadinovirus) (45, 50) is etiologically linked with Kaposi's sarcoma (KS), a multifocal endothelial cell tumor most commonly seen in AIDS patients (14). KS lesions are characterized by the presence of spindle-shaped endothelial cells and inflammatory cells. Several lines of evidence point to a central role of KSHV in the pathogenesis of KS and in the pathogenesis of two B cell-proliferative disorders, primary effusion lymphoma or body cavity-based B-cell lymphomas (BCBL) and multicentric Castleman's disease (53). Cell lines with B-cell characteristics established from BCBL carry KSHV in a latent

No abstract

No abstract