Background and Aims:Hyponatremia is the predominant electrolyte abnormality with an incidence rate of approximately 22%. It is the leading cause of morbidity and mortality with scarce data in Indian intensive care settings. The aim of this study is to evaluate the clinical features and etiology of hyponatremia in patients admitted to an Intensive Care Unit (ICU) of a tertiary care hospital.Materials and Methods:A 1-year prospective cross-sectional observational study was conducted, including 100 adult patients with moderate-to-severe hyponatremia admitted to the Medical ICU. Patients underwent investigations such as serum creatinine, blood urea nitrogen, serum osmolality, serum sodium, urine sodium, and urine osmolality, sputum culture, cerebrospinal fluid analysis, and neuroimaging. Data were analyzed using independent sample t-test, Chi-square test, and Fisher's exact test.Results:Vomiting (28) followed by confusion (26) was the most common complaint. Syndrome of inappropriate antidiuretic hormone secretion (SIADH) (46) was the most common etiology for hyponatremia, and euvolemic hypoosmolar hyponatremia (50) was the most common type of hyponatremia. Confusion was significantly high in patients with severe hyponatremia as compared to patients with moderate hyponatremia (22 vs. 4, P < 0.001). In majority of the patients (46), SIADH was the main cause of euvolemic type of hyponatremia (P < 0.001). Increased urine sodium levels were observed in patients with SIADH (46), renal dysfunction (12), and drug-induced etiology (8, P < 0.001).Conclusion:Patients with hyponatremia secondary to an infectious cause should be meticulously screened for tuberculosis. The timely and effective treatment of hyponatremia is determined by the effective understanding of pathophysiology and associated risk factors of hyponatremia.
Introduction
During identification and diagnosis, typhoid fever (TF) causes various issues such as nonspecific symptoms and nontyphoidal
Salmonella-
associated febrile diseases. Accurate identification and diagnosis are still a substantial concern. The current study was undertaken to study the clinical profile of TF and the role of Typhifast IgM and Enterocheck WB in early diagnosis.
Materials and methods
Clinically suspected TF patients (121) were included in the study. Patients with antibiotic history during the period of febrile illness were excluded. The diagnosis was confirmed with blood culture test. Widal test and two new rapid serological tests: Typhifast IgM and Enterocheck WB were performed. The outcomes were compared with blood culture-confirmed cases to derive the sensitivity and specificity of the diagnostic tests. The clinical characteristics were compared with diagnostic tests using Chi-square test.
Results
The most common presentations of TF were fever, chills, vomiting, abdominal pain, anorexia, constipation, and diarrhea. Among the 121 clinically suspected TF patients, 67 had positive blood culture tests for
Salmonella typhi
. The Typhifast IgM and Enterocheck WB showed sensitivity of 97.01% and 68.52%, respectively. Specificity was also more with Typhifast IgM (85.07%) than with Enterocheck WB (62.96%). When tests were used in parallel combination, 97.01% sensitivity was attained, while the specificity dropped to 46.30%. When used in serial combination, sensitivity of 85.07% and specificity of 85.19% were observed.
Conclusion
Stepladder fever, abnormal serum glutamic oxaloacetic transaminase (SGOT), and abnormal albumin are associated with blood culture, Typhifast IgM, and Enterocheck WB tests. Rapid serological tests might assist in accurate and early identification of TF.
How to cite this article
Bhume RJ, Babaliche P. Clinical Profile and the Role of Rapid Serological Tests: Typhifast IgM and Enterocheck WB in the Diagnosis of Typhoid Fever. Indian J Crit Care Med 2020;24(5):307–312.
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