Leishmaniasis, the second most neglected
tropical disease, has
been reported to affect approximately 12 million people worldwide.
The causative protozoan parasite Leishmania has shown
drug resistance to available chemotherapies, owing to which we need
to look for better approaches to deal with the clinical situations.
As per recent reports, several miRNAs have been found to be differentially
expressed during Leishmania major infection
in host macrophages. We aim to evaluate the impact of miRNA-mediated
gene regulation on the key players of inflammation and macrophage
dysfunction. The origin of Leishmania miRNAs and
their processing is a questionable phenomenon as of yet. Through our
study, we aim to provide a framework of their characterization. We
amalgamate chemical systems biology and synthetic biology approaches
to identify putative miRNA targets and unravel the complexity of host–pathogen
gene regulatory networks.
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