Systems pharmacology aiding benzimidazole scaffold as potential lead compounds against leishmaniasis for functional therapeutics

Kumar, Anurag; Nimsarkar, Prajakta; Singh, Shailza

doi:10.1016/j.lfs.2022.120960

Cited by 4 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kumar et al . performed a virtual screening of 221 compounds from several online databases (PubMed, ChEMBI, DrugBank) by using the predicted TryR structure [ 88 ]. Fifty-five compounds that resulted from the screening were able to bind the enzyme, and among them, 7 satisfied the docking score threshold of -7.00 kcal/mol.…”

Section: Benzimidazole-based Compounds Active Against Malaria Leishma...mentioning

confidence: 99%

State-of-the-art Review on the Antiparasitic Activity of Benzimidazolebased Derivatives: Facing Malaria, Leishmaniasis, and Trypanosomiasis

Francesconi,

Rizzo,

Schenone

et al. 2024

CMC

View full text Add to dashboard Cite

Protozoan parasites represent a significant risk for public health worldwide, afflicting particularly people in more vulnerable categories and cause large morbidity and heavy economic impact. Traditional drugs are limited by their toxicity, low efficacy, route of administration, and cost, reflecting their low priority in global health management. Moreover, the drug resistance phenomenon threatens the positive therapy outcome. This scenario claims the need of addressing more adequate therapies. Among the diverse strategies implemented, the medicinal chemistry efforts have also focused their attention on the benzimidazole nucleus as a promising pharmacophore for the generation of new drug candidates. Hence, the present review provides a global insight into recent progress in benzimidazole-based derivatives drug discovery against important protozoan diseases, such as malaria, leishmaniasis and trypanosomiasis. The more relevant chemical features and structure-activity relationship studies of these molecules are discussed for the purpose of paving the way towards the development of more viable drugs for the treatment of these parasitic infections.

show abstract

Section: Benzimidazole-based Compounds Active Against Malaria Leishma...mentioning

confidence: 99%