Introduction: Increased mean platelet volume is a known risk factor for various acute vascular complications, which is commonly associated with patients with diabetes mellitus. This study was aimed to investigate the association of Mean Platelet Volume (MPV) with Type 2 Diabetes Mellitus (DM) and to know the difference of MPV in patients on oral hypoglycaemic drugs and insulin therapy.
Material and Methods:A total of 150 patients were selected and allocated to three Groups of 50 each, referred to as DM Group on insulin therapy, DM Group on oral hypoglycaemic therapy and non-DM Group (Negative control Group). Investigations like fasting blood glucose, HB A1c and MPV were performed. Difference between the means of age, MPV were calculated by analysis of variance (ANOVA) by using Tukey's Honestly Significant Difference (HSD) test. p-value and Confidence intervals were also calculated (p<0.05).Result: The outcome of study has shown that values of MPV are increased in patients with Type 2 DM, and are significantly higher in those patients on oral hypoglycaemic therapy than patients on insulin therapy.
Conclusion:MPV is a simple and cost-effective tool which can be explored for predicting the possibility of acute vascular events in patients suffering from diabetes mellitus. Values of MPV are increased in patients with uncontrolled Type 2 DM, and are significantly higher in diabetic patients treated with oral hypoglycaemic therapy than in those patients on insulin therapy. Early initiation of insulin treatment in confirmed cases of Type 2 diabetics not only helps in controlling blood glucose level but also helps in keeping MPV low and thereby preventing possibility of impending acute vascular events.
Plasmodium falciparum infection (either alone or along with P. vivax) is the leading cause of malarial hepatopathy. Jaundice is a common clinical manifestation among these patients. Patients with malarial hepatopathy have increased incidences of hypoglycemia and thrombocytopenia. Malarial hepatopathy occurs in relation to severe infection, most of which are treated with parenteral artesunate.
Malaria is a major health problem in the tropics with increased morbidity and mortality. Plasmodium vivax is the most frequent and widely distributed cause of recurring malaria worldwide. Plasmodium vivax malaria is endemic infection in India and is commonly associated with haematological abnormalities, Thrombocytopenia is frequently observed in vivax malaria but the exact mechanism has not been elucidated. It has been increasingly observed that P. vivax malaria, which was otherwise considered to be benign malaria, with a low case-fatality ratio, can also occasionally result in severe disease as with P. falciparum malaria. This study was undertaken to correlate the presence and severity of thrombocytopenia with P. vivax malaria.
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