<p><strong>Background: </strong>Disorders affecting the genitalia are a global health problem of significant magnitude. They comprise conditions which may or may not be sexually transmitted. Often it becomes impossible to make a reliable etiological diagnosis on clinical grounds alone. There is a paucity of data about the burden and pattern of genital disorders in our setting. This study was undertaken to identify the prevalent trends and clinic-etiological profile of genital lesions.</p><p><strong>Methods: </strong>100 consecutive cases presenting with genital disorders to dermatology OPD of Sassoon General Hospital, Pune, India from June 2019 to March 2020, were enrolled in this observational, cross sectional study. Patients were subjected to thorough history, clinical examination and requisite microbiological and serological investigations. Etiological diagnosis was reached after correlation of history, clinical findings and investigations.</p><p><strong>Results:  </strong>100 patients comprised 70 males and 30 females. Age group ranged from 2 months to 75 years (mean 37.8 years). Majority of patients belonged to 21-30 years age group.  Total 78% patients had (STI) while 22% had non-STI. 13% were HIV sero-positive. 12% patients were diabetic. In 54% cases, microbiological findings confirmed the clinical diagnosis.</p><p><strong>Conclusions: </strong>This study emphasizes that sexually transmitted infections continue to be a prominent cause of genital lesions, particularly in young sexually active individuals. However, various non-venereal dermatological disorders may manifest on the genitalia at any age, leading to diagnostic difficulty. A meticulous clinical examination supported by appropriate laboratory evaluation is the key to distinguish venereal and non-venereal dermatoses.</p><p><strong> </strong></p>

Melasma is a common acquired circumscribed hyper-pigmentary disorder involving sun-exposed areas, particularly face. The high frequency of recurrence renders the management more challenging. Autologous platelet rich plasma (PRP) has promising potential in the treatment of melasma. This study evaluates the efficacy of combination of autologous PRP and Hydroquinone and compares it with the gold standard molecule 4% Hydroquinone. Thirty patients with melasma were enrolled in this splitface study conducted between 2018 and 2020. All the patients were prescribed Hydroquinone cream 4% to be applied on the affected area at night. Microneedling was performed once a month (total four sessions) on both sides of face, followed by application of autologous platelet rich plasma on right side and normal saline as control on left side of affected area. Modified Melasma Area and Severity Index (MASI) score, Patient satisfaction score and Physician's Global Assessment score were calculated at baseline and after each session and improvement was assessed. Improvement in mean modified MASI score was significant on both sides of face. Mean percentage improvement in modified MASI score on study side and control side was 82% and 69% respectively. The difference between the two sides was statistically significant in terms of modified MASI, patient satisfaction and physician global assessment scores. Adverse effects were mild and transient. Autologous platelet rich plasma is an effective and safe therapy for treatment of melasma. Combination of autologous PRP and 4% Hydroquinone showed greater improvement than hydroquinone alone.