In cases of orofacial rehabilitation, quality of life depends upon the outcome of treatment provided by a maxillofacial management team that usually includes oral surgeons, radiologists, prosthodontists, speech specialists and plastic surgeons. Patients with maxillofacial defects often suffer from disturbed psychological status and are often treated as stigma to the society. Prosthodontists have a key role in restoring aesthetics and occlusion of such patients which ultimately aids improve the psychological status and quality of life of such patients. The prosthetic rehabilitation on compromised tissue beds requires meticulous treatment planning and precise execution. Short-listing treatment options become an enigma if conventional approaches for maxillofacial rehabilitation are contraindicated. The following series describes cases of suspected Brown’s tumour (primary hyperparathyroidism) and an odontogenic keratocyst of the mandible in which conventional grafting and implant prostheses were not indicated.
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