Background: In this study the chemotherapeutic effects of docetaxel and gene expression of epidermal growth factor receptor (EGFR) during regression of mammary tumour in canines were evaluated.Methods: Sixteen dogs suffering from canine mammary tumour were randomly divided into two groups viz. I and II and subjected to Docetaxel @ 30mg/m2 weekly, four consecutive cycles, (Group I) and surgical excision of tumour followed by chemotherapy with Docetaxel @ 30mg/m2 weekly, four consecutive cycles, (Group II). The therapeutic efficacy was assessed by clinical, radiological, ultrasonography, haemato-biochemical and histopathological evaluation including gene expression profiling of EGFR using Real-time PCR analysis.Result: On the basis of the above parameters studied it was concluded that combination of surgery and chemotherapy using docetaxel is an effective treatment for the regression of mammary tumour and can be used safely by the field veterinarian. Real-time PCR analysis also revealed down-regulation of EGFR gene in group II.
Results: There was a total of 25 patients with skull base meningiomas, out of which 9 of them were located in the cavernous sinus area. There were 6 female and 3 male patients. The mean age of the patients was 50.6 (36-70) years. The mean follow-up time postradiosurgery was 6.67 (4-12) months. The mean tumor volume before radiosurgery was 12.36 (1.51-34.45) cm 3 . The mean tumor volume after radiosurgery was 10.19 (0.98-28.80) cm 3 . The dose used was between 12 to 18 gray. Post-radiosurgery, clinical symptoms such as hypesthesia improved in 1 out of 2 patients (50%), seizures improved in 100% of patients, blurred vision improved in 2 out of 4 patients (50%), cranial nerve III, IV and VI function improved in 2 out of 4 patients (50%), headaches was no longer present in 50% patients and double vision improved in 100% of patients. Conclusions: Gamma knife radiosurgery reduces the tumor size and improves the clinical symptoms in patients with cavernous sinus meningiomas. However, large prospective studies should be done in order to further evaluate the long term effects of gamma knife for skull base meningiomas.
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