Various 2-amino-N-{3-(2 ,5-disubstituted-1H-indol-3-yl)methylene}-4,5-dimethylthieno-3carbohydrazides (3) synthesized by condensation of 2-amino-4,5-dimethyl thiophene-3-carbohydrazide (2) with 2,5-disubstituded indole-3-carboxaldehyde (1). The Schiff's base (3) on cyclocondensation with acetic anhydride and triethyl orthoformate afforded thienopyrimidine analogues (4) and (7), respectively. Compounds 4 or 7 on cyclization with thioglycolic acid and chloroacetyl chloride gave thiazolidin-4-ones (5) or (8) and azitidin-2-ones (6) or (9) respectively. The structures of these newly synthesized compounds have been established on the basis of their spectral data and elemental analysis. Some of the compounds exhibited promising antioxidant and antimicrobial activities.
Several 5-(2', 5'-disubstituted 1H-indol-3'-yl)-5H-thiazolo[4,3-b]l,2,4-triazoles (5) -1,3,4-thiadiazoles (6) and 1,3,4-oxadiazoles (7) and their analogues were synthesized. These compounds were screened for their antimicrobial activity.
2-N-(2-Phenyl-1H-indol-3-yl)imino-4-arylthiazoles (3a–c) were used as key synthons for the preparation of (4-arylthiazol-2-yl)-4-(2-phenyl-1H-indol-3-yl)azetidin-2-ones (4a–c) and 3-(4-arylthiazol-2-yl)-2-(2-phenyl-1H-indol-3-yl)thiazolidin-4-ones (5a–c). These newly synthesized compounds have been characterized with the help of IR,1H NMR,13C NMR, and mass spectral studies. All compounds were screened for their antioxidant, antimicrobial, antimycobacterial, and cytotoxic activities. Some of the compounds displayed excellent activity.
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