1 Plasma salicylate concentrations and salicylate clearances were evaluated in 10 patients before and then 3 days after the intra-articular administration of glucocorticoid steroids.All patients were on chronic salicylate treatment, the dosage varying from 1.3-4.6 g day-1 of enteric-coated aspirin. 2 The mean steady state plasma concentration (+ s.e. mean) of salicylate decreased significantly after intra-articular steroid (90.9 + 14.8 mg 1-1 -64.7 + 8.9, P < 0.05), whilst the mean clearance increased significantly (87.3 + 20.6 ml min-1-120.6 + 28.3, P < 0.05). 3 In these paired studies, the intra-articular administration of steroids lead to a significant decrease in plasma salicylate levels in patients taking enteric-coated aspirin.
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