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A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR, 1 H NMR, 13 C NMR and mass spectral data confirmed the structure of the synthesized compounds. The derivatives of these moieties were evaluated for anticonvulsant activity by MES model and neurotoxicity by rotarod method. The synthesized compounds showed good potential for anticonvulsant activity besides this, the compounds also showed neurotoxic effect. It was observed that compounds with OCH3 at 3, 4 position of phenyl ring [5(a-l)] showed less protection against convulsions as compared to compounds having unsubstituted phenyl ring [4(a-l)].

A series of thiadiazole derivatives were synthesized with differently substituted benzoic acids which were cyclized to give differently substituted thiazolidin-4-one. Elemental analysis, IR, 1 H NMR, 13C NMR and mass spectral data confirmed the structure of the newly synthesized compounds. The derivatives of these moieties were evaluated for antimicrobial activity. Most of the synthesized compounds showed good antimicrobial activity at 200 and 100 µg/mL. Compounds showed most significant antibacterial activity against gram negative test organism Escherichia coli and most significant antifungal activity against test organisms Aspergillus niger and Candida albicans. It was observed that compounds with OCH3 at 3, 4 position of phenyl ring [5(a-l)] were more potent against microbes as compared to compounds having unsubstituted phenyl ring [4(a-l)].

535.243An attempt was made to develop and validate a novel, simple, cost effective, accurate, and reproducible UVspectrophotometric method to estimate mycophenolate mofetil in bulk and pharmaceutical formulations. Mycophenolate mofetil was estimated at 250 nm in 0.1N hydrochloric acid (pH 1.2) and in acetate buffer (pH 4.5).Beer's law was obeyed in the concentration range of 5-40 μg/ml in hydrochloric acid and in the acetate buffer medium. The methods were tested and validated for various parameters according to ICH guidelines. The proposed methods were successfully applied for the determination of mycophenolate mofetil in pharmaceutical formulations (tablets and capsules). The results demonstrate that the procedure is accurate, precise, and reproducible (relative standard deviation <2%) while being simple, cheap, and less time-consuming, and hence can be suitably applied for the estimation of mycophenolate mofetil in different dosage forms and for dissolution studies.

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