Introduction: Oral route is the most common and convenient route to deliver the drug. Many oral drug delivery systems were developed to improve drug bio availability; gastro retentive drug delivery system is one of them. Gastroretentive drug delivery system is the system in which a drug can remain in the gastric region for several hours in order to prolong its gastric residence time. The purpose of this work was to develop and evaluate rebamipide loaded gastro retentive alginate based muco adhesive beads. Materials and Methods: Rebamipide loaded alginate beads were prepared by ionotropic gelation and polyelectrolyte complexation method. Prepared beads were characterized for IR, DSC, SEM and evaluated for dissolution and stability studies. Results: The FTIR spectra revealed that there were no interaction between drug and excipients. The particle size analysis showed that beads with 3% of sodium alginate were spherical in shape. The mucoadhesion study reveals that as concentration of alginate and carbopol 934 increases percentage of mucoadhesion also increases. Conclusion: From in-vivo study it was concluded that the prepared formulation showed better control on ulcer than that of pure rebamipide. Rebamipide was successfully formulated as gastroretentive floating and mucoadhesive alginate beads by using ionotropic gelation and polyelectrolyte complexation method.
Luffa acutangula (Cucurbitaceae), an enduring plant fills primarily in India, Southeast Asia, China, Japan, Egypt, and different pieces of Africa, it is generally utilized in the customary Indian restorative framework to treat different ailments. The plant has been utilized in jaundice, diabetes, hemorrhoids, diarrhea, cerebral pain, ringworm disease, and uncleanliness. In excess of 50 substance compounds have been disengaged from a plant which chiefly includes flavonoids, anthraquinones, proteins, unsaturated fats, sapon in triterpene, unstable parts, and other phytoconstituents. Unrefined concentrate of plant and its secluded mixtures have expansive pharmacological exercises like antidiabetic, hepatoprotective, antiulcer, anticancer, immunomodulatory, antihyperlipidemic, cell reinforcement, antimicrobial, CNS depressant, pain relieving, and calming. The toxicological assessment in preclinical investigations detailed wellbeing of the plant for human utilization, yet thorough assessment in clinical examinations is required. Notwithstanding, further examination is important for change of involvement based treatment of plant into proof based data. Assessment of pharmacological movement with characteristic biomarkers will assist with uncovering the instrument of activity of compound constituents of plant remove. The information from preclinical investigations suggests clinical assessment of security and viability of the plant. The current paper sums up forward-thinking data about a survey of the customary uses, phytochemistry, pharmacological exercises, and toxicology to feature the future possibilities of the plant.
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