An efficient approach towards the synthesis of 6-aryl-4-azidocinnolines was developed with the aim of exploring the photophysical properties of 6-aryl-4-azidocinnolines and their click reaction products with alkynes, 6-aryl-4-(1,2,3-1H-triazol-1-yl)cinnolines. The synthetic route is based on the Richter-type cyclization of 2-ethynyl-4-aryltriazenes with the formation of 4-bromo-6-arylcinnolines and nucleophilic substitution of a bromine atom with an azide functional group. The developed synthetic approach is tolerant to variations of functional groups on the aryl moiety. The resulting azidocinnolines were found to be reactive in both CuAAC with terminal alkynes and SPAAC with diazacyclononyne, yielding 4-triazolylcinnolines. It was found that 4-azido-6-arylcinnolines possess weak fluorescent properties, while conversion of the azido function into a triazole ring led to complete fluorescence quenching. The lack of fluorescence in triazoles could be explained by the non-planar structure of triazolylcinnolines and a possible photoinduced electron transfer (PET) mechanism. Among the series of 4-triazolylcinnoline derivatives a compound bearing hydroxyalkyl substituent at triazole ring was found to be cytotoxic to HeLa cells.
Cu-catalyzed 1,3-dipolar cycloaddition of ethyl 2-azidoacetate to iodobuta-1,3-diynes and subsequent Sonogashira cross-coupling were used to synthesize a large series of new triazole-based push–pull chromophores: 4,5-bis(arylethynyl)-1H-1,2,3-triazoles. The study of their optical properties revealed that all molecules have fluorescence properties, the Stokes shift values of which exceed 150 nm. The fluorescent properties of triazoles are easily adjustable depending on the nature of the substituents attached to aryl rings of the arylethynyl moieties at the C4 and C5 atoms of the triazole core. The possibility of 4,5-bis(arylethynyl)-1,2,3-triazoles’ application for labeling was demonstrated using proteins and the HEK293 cell line. The results of an MTT test on two distinct cell lines, HEK293 and HeLa, revealed the low cytotoxicity of 4,5-bis(arylethynyl)triazoles, which makes them promising fluorescent tags for labeling and tracking biomolecules.
In the current conditions, regional independence in the implementation of budgetary powers and the role of effective management of financial flows at the subnational level are significantly increasing. The priority area of territorial development is leveling socio-economic differentiation by accumulating their own resource capabilities, rather than financial assistance from a higher budget. Sustainable development of the region should be based on effective management of financial and investment potential based on the principles of financial meta-management.
Статья посвящена проблемам управления финансово-инвестиционным потенциалом региона в контексте устойчивого развития. Целью исследования выступает определение основ управления устойчивым финансово-инвестиционным потенциалом региона в контексте устойчивого развития. Объектом исследования являются финансовоинвестиционный потенциал региона и показатели его устойчивого развития. Научная новизна заключается в разработке концептуальных основ управления финансово-инвестиционным потенциалом региона в целях его устойчивого развития.
The article is devoted to the problems of managing the financial and investment potential of the region in the context of sustainable development. The purpose of the study is to determine the fundamentals of managing the sustainable financial and investment potential of the region in the context of sustainable development. The object of the study is the financial and investment potential of the region and indicators of its sustainable development. The scientific novelty lies in the development of conceptual foundations for managing the financial and investment potential of the region for its sustainable development.
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