BACK GROUND:To study and compare the efficacy and safety of intra vaginal misoprostol versus intra cervical dinoprostone gel for cervical ripening and induction of labour. Objectives: 1. To study and compare efficacy and safety of misoprostol and dinoprostone gel. 2. To study the success rate and outcome of induction 3. To Study the average induction -delivery interval 4. To study the side effects during induction with these drugs. DESIGN: It is a prospective study. STUDY AREA: Department of Obstetrics & Gynecology, Government General Hospital, Guntur, affiliated to Guntur Medical College. STUDY SUBJECT: Antenatal Women. SAMPLE SIZE: 100 Antenatal women who were admitted in Antenatal ward in Department of Obstetrics. STUDY PERIOD: September 2013 to September 2014. RESULTS: 100 antenatal women requiring induction of labour were followed 50 received 25 g misoprostol 4 th hourly, 0.5 mg of intracervical dinoprostol gel 12 hourly. The result of the study shows induction delivery interval was significantly shorter in misoprostol group than dinoprostone group. Caesarean section rate is low in misprostol group compared to dinoprostone group. With the lower dosage of misoprostol, no maternal complications were observed and foetal complication i.e., meconium stained liquor was seen in 8% of misoprostol group, but Apgar score was good in both group. CONCLUSION: On basis of our study misoprostol is an effective and safe drug to mother and foetus, easy to administer, and stable at room temperature, and misoprostol is a cheaper drug better and effective alternate to dinoprostone gel in a women belonging to resource constrained developing countries.
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