Introduction: Novel coronavirus disease is a very infectious respiratory infection transmitted from person-to-person and manifest commonly with fever, dry cough, difficulty breathing, fatigue, myalgia and dyspnea. The World Health Organization (WHO) used the term 2019 novel coronavirus to refer to a coronavirus that affected the lower respiratory tract of patients with pneumonia in Wuhan, China on 29 December 2019. Persons with comorbidities and the aged are most vulnerable to severe disease and accounted for over 40% of deaths globally. Methods:A cross-sectional study involving 320 adult males and females above the age of 18 years was conducted across all seven sub-districts of the Kintampo North Municipal. A total of 21 communities were selected by random sampling and 15 individuals interviewed. Systematic sampling was used to select 15 houses in each community and one household selected by simple random sampling if more than one household in a house. Simple random sampling was used to select one participant for inclusion in the study. Stata version15 software was used for the analysis and reported in frequencies and percentages. Bivariate and multivariate analysis was further conducted to find associations between adherence to COVID-19 safety protocols and the demographic and main variables of the study.Results: About 98% of the study participants demonstrated high level of awareness regarding COVID-19. Even though about 82% of participants reported to be practicing hand washing under running water, almost of all (81.9%) do not satisfy the correct hand washing procedure. The study found significant association between education and adherence to COVID-19 safety protocols. Even though the level of awareness was very high, the study revealed that about 94% of the participants are not adhering to the various preventive measures recommended by the Ministry of Health. About 28.3% of the study participants do not know any sign or symptom of COVID-19. About 95% of the participants are worried about getting infected with COVID-19 and 96% knows the importance of wearing nose mask even though only 24.2% used a nose mask. Conclusion:There is high level of awareness about COVID-19 in the public mostly through the media but most of the people do not adhere to the preventive measures to prevent themselves from infection. Intensified education and enforcement of the preventive measures will be required to interrupt the chain of transmission since the level of awareness seems not to translate to actual practice of preventing infection.