Bind and shine: An approach for the selective detection of both enzymes and non‐enzymatic proteins using an environment‐sensitive fluorescent turn‐on probe is described (see scheme). This approach targets the hydrophobic ligand‐binding domain of the target protein to trigger the fluorescence turn‐on and was shown to be specific for the targeted protein.

In the presence of target analyte, bright fluorescence in the near-IR region is emitted through the recognition-induced disassembly of the probe aggregate.

The goal of this study is to analyze the adverse drug events, using the human factors analysis and classification system (HFACS), and to identify the causality between the error factors. Twenty-five cases related to medication errors were identified. Seven experts were recruited to form an expert team for this study. The HFACS and root cause analysis were utilized in this study to identify the causal factors and the root causes of medication errors. The frequency of each error factor was recorded, and odds ratio was applied to measure the strength of the relevance of the error factors between adjacent levels of the HFACS. The results showed that 222 errors were identified and the main pathways and subpathways of medication errors from Level 4 to Level 1 of the HFACS were arranged in this study. According to the results, the deficiencies in organizations could be the main reasons causing adverse drug events in Taiwan. K E Y W O R D S adverse drug event, causality analysis, human error, human factors analysis and classification system (HFACS), patient safety

Bei Bindung Licht an: Eine umgebungsempfindliche „anschaltbare“ Fluoreszenzsonde ermöglicht die selektive Detektion von Enzymen wie auch nichtenzymatischen Proteinen (siehe Schema). Zum Anschalten der Fluoreszenz wird dabei die hydrophobe Ligandbindungsdomäne des Zielproteins angesteuert. Die Methode ist spezifisch für das jeweilige Zielprotein.