17We developed mid-infrared optoacoustic microscopy (MiROM), a bond-18 selective imaging modality that overcomes water/tissue opacity and depth 19 limitations of mid-infrared sensing allowing uncompromised live-20 cell/thick-tissue mid-infrared microscopy with up to three orders of 21 magnitude higher sensitivity than other vibrational imaging modalities; 22 such as Raman. We showcase the functional label-free biomolecular 23 imaging capabilities of MiROM by monitoring the spatiotemporal 24
dynamics of lipids and proteins during lipolysis in living adipocytes. Since 25MiROM, contrary to Raman modalities, is not only able to detect lipids and 26 proteins, but also important metabolites such as glucose without the need 27
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