Background Different technique for ceramic veneering and thermal tempering process are expected to be a reason for alteration in strength of ceramic veneered zirconia. This study evaluates the effect of different veneering technique and varied thermal tempering process on flexural strength of ceramic veneered zirconia. Material and Methods Ceramic veneered zirconia bars (25 mm length, 4 mm width, 0.7&1.0mm of zirconia & ceramic thickness) were prepared from zirconia block (e.max® ZirCAD), sintered at 1500°C for 4 hours, and veneered with ceramics with different techniques including CAD-fused using e.max CAD® (C), Pressed-on using e.max® Zirpress (P), and layering using e.max® ceram (L), with different tempering process through fast (F), medium (M), and slow (L) cooling (n=15). The specimens were determined for flexural strength on a universal testing machine. ANOVA and Bonferroni’s multiple comparisons were used to determine for significant difference (α=0.05). Weibull analysis was applied for survival probability, Weibull modulus (m), and characteristics strength (σc). The interfaces were microscopically examined. The phase transformation of zirconia was determined using X ray diffraction. Results The mean±sd (MPa), m, σc of flexural strength were 922.06±83.45, 12.78, 958.32 for CF, 924.26±74.64, 14.28, 959.62 for CM, 930.25±92.42, 11.83, 970.83 for CS, 518.29±59.97, 10.11, 542.97 for PF, 516.50±67.51, 8.75, 539.17 for PM, and 520.51±42.38, 14.59, 544.51 for PS, 604.36±64.09, 11.28, 630.67 for LF, 583.81±56.95, 11.67, 609.81 for LM, 547.33±52.23, 12.19, 569.36 for LS. The flexural strength was significantly affected by veneering technique ( p <0.05). No significant effect on flexural strength upon tempering process was evidenced ( P >0.05). Phase transformation from t→m related with veneering and tempering procedure. Conclusions Strength of ceramic veneered zirconia associated with different veneering techniques, but not directly related with tempering process. CAD-on ceramic veneering zirconia is benefit for enhancing the strength of ceramic bilayer and was recommended as a method for ceramic veneering zirconia. Key words: CAD-CAM, cooling process, flexural strength, thermal tempering, zirconia.