In this work, the relaxation parameter (τ) and fractionality order (α) in the fractional single phase lag (FSPL) non-Fourier heat conduction model are estimated by employing the conjugate gradient inverse method (CGIM). Two different physics of skin tissue are chosen as the studied cases; single and three-layer skin tissues. Single-layer skin is exposed to laser radiation having the constant heat flux of Qin. However, a heat pulse with constant temperature is imposed on the three-layer skin. The required inputs for the inverse problem in the fractional diffusion equation are chosen from the outcomes of the dual phase lag (DPL) theory. The governing equations are solved numerically by utilizing implicit approaches. The results of this study showed the efficiency of the CGIM to estimate the unknown parameters in the FSPL model. In fact, obtained numerical results of the CGIM are in excellent compatibility with the FSPL model.
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