Public reporting burden for the collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden, to Washington Headquarters Services, Directorate for Information Operations and Reports, 1215 Jefferson Davis Highway, Suite 1204, Arlington VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to a penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION/AVAILABILITY STATEMENTApproved for public release; distribution unlimited SUPPLEMENTARY NOTESThe original document contains color images. ABSTRACTThe purpose of this study was to compare and contrast the effects of single 3.8-micron laser pulses in an in-vitro and in-vivo model of human skin and to demonstrate the efficacy of in-vitro laser tissue interaction models. The minimum exposure required to produce specific, gross morphologic changes from a four microsecond, pulsed skin exposure for both models was determined. Histologic samples of the tissues were compared to ascertain the effectiveness of the in-vitro models. Eighteen artificial skin equivalents, (in-vitro model), were exposed and compared to exposures made on five Yorkshire pigs. Representative biopsies were taken for histologic evaluation from various locations immediately, one hour, and 24 hours following exposure. The pattern of epithelial changes seen following in-vivo exposure of pig skin was similar to the changes previously observed in human skin equivalents, indicating that the artificial skin equivalents are representative in-vitro models for this particular combination of laser parameters. The author hereby certifies that the use of any copyrighted material in the thesis manuscript entitled:"Comparison of Experimental Models for Predicting Laser Tissue Interaction from 3.8-micron Lasers" beyond brief excerpts is with the permission of the copyright owner, and will save and hold harmless the Uniformed Services University of the Health Sciences from any damage, which may arise from such copyright violations.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.