by on July 31, 2020. For personal use only. jnm.snmjournals.org Downloaded from ABSTRACT Radiomics is a rapidly evolving field of research concerned with the extraction and quantification of patterns -the so-called radiomic features -within medical images. Radiomic features capture tissue and lesion characteristics such as heterogeneity and shape, and may, alone or in combination with demographic, histological, genomic or proteomic data, be used for clinical problem-solving. The goal of this CE article is to provide an introduction to the field, covering the basic radiomics workflow:feature calculation and selection, dimensionality reduction, and data processing . Potential clinical applications in nuclear medicine that include PET radiomics-based prediction of treatment response and survival will be discussed. Current limitations of radiomics, such as sensitivity to acquisition parameter variations, and common pitfalls will also be covered.

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