-I n t roduction: Angiostrongylus cantonensis meningoencephalitis is an emergent disease in the A m e r i c a s . Method: Twelve children suffering from eosinophilic meningoencephalitis due to this parasite aged between 6-10 years were studied. Cerebrospinal fluid (CSF) and serum samples were taken simultaneously in the first diagnostic puncture at admission. Results: All cases showed typical findings on the routine CSF and serum analysis: increased CSF total protein, increased Q (CSF/serum) albumin accompanied by eosinophilia in CSF. No intrathecal synthesis of immunoglobulins was found. Mean serum and CSF sICAM-1 values were 337.4 and 3.97 ng/mL. Qalbumin and QsICAM-1 mean values were 4.1 and 6.2 respectively. In 50% of the patients an increased brain-derived fraction of sICAM-1 was found. Conclusion: It may be suggested that a dynamic of the sICAM-1 brain derived fraction is perhaps associated to the immune response in the evolution of the disease.sICAM-1 may be an agent in negative feedback for eosinophils passage through the blood-CSF barrier into the inflammatory brain response.KEY WORDS:A n g i o s t rongylus cantonensis, albumin, sICAM-1, blood-cere b rospinal fluid barr i e r, eosinophils, meningoencephalitis.sICAM-1 en meningoencefalitis por Angiostrongylus cantonensis. RESUMEN -I n t roducción: La meningoencefalitis por A n g i o s t rongylus cantonensises una enfermedad emergente en las Américas. Método: Doce niños con meningoencefalitis eosinofílica porA n g i o s t rongylus cantonensis con edades entre 6 y 10 años fueron estudiados. Se tomaron muestras simultáneas de suero y líquido cefalorraquídeo (LCR) en la primera punción lumbar diagnóstica. Resultados: Todos los casos evid e n c i a ron hallazgos típicos en los análisis de rutina del LCR y suero: incremento de proteínas totales, aumento de la razón albúmina Q (LCR/suero) acompañado de eosinofilia en LCR. No se encontró síntesis intratecal de inmunoglobulinas. Los valores medios de sICAM-1 en suero y LCR fueron de 337,4 y 3,97 ng/mL respectivamente. Los valores medios de Q albúmina y Q sICAM-1 fueron de 4,1 y 6,2 respectivamente. En el 50% de los pacientes se encontró un incremento de la fracción de sICAM-1 derivado del cere b ro . C o nclusión: Se puede sugerir que la dinámica de la fracción sICAM-1 derivada del cere b ro ocurre quizas asociada a la respuesta inmune frente a la enfermedad. sICAM-1 puede ser un agente de retroalimentación negativa para el paso de eosinófilos de la sangre a través de la barrera sangre-LCR en el cerebro inflamado. PALABRAS CLAVES:A n g i o s t rongylus cantonensis, albúmina, sICAM-1, barrera sangre/líquido cefalorr a q u í d e o , eosinófilos, meningoencefalitis.Eosinophilic meningitis (EM) is a distinct clinical entity that may have both infectious and noninfectious causes. Worldwide, infection with the helminthic parasite, A n g i o s t rongylus cantonensis, is the most common infectious etiology 1,2 .A n g i o s t rongylus cantonensis is a parasite that infects rats as principal hosts and then several...
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