Background To compare the efficacy and safety of preoperative intravitreal injections of ranibizumab and conbercept in Chinese proliferative diabetic retinopathy (PDR) patients. Methods This prospective randomized controlled trial enrolled 90 eyes of 80 patients with PDR. Forty-four eyes of 40 patients that received intravitreal ranibizumab (IVR) injections (0.5 mg/0.05 mL) before vitreous surgeries were assigned to the IVR group. Forty-six eyes of 40 patients that received intravitreal conbercept (IVC) injections (0.5 mg/0.05 mL) before vitreous surgeries were assigned to the IVC group. Intraoperative and postoperative indices were assessed for further comparison between the two groups. Results There were no statistically significant differences in all surgery indices, including intraoperative indices (surgery time, P = 0.225; intraoperative bleeding, P = 0.808; endodiathermy use, P = 0.693; incidence of iatrogenic retinal breaks, P = 0.740; relaxing retinotomy, P = 0.682; retinal reattachment, P = 0.682 and silicone oil tamponade, P = 0.814) and postoperative indices (postoperative vitreous hemorrhage (VH), P = 0.808; neovascular glaucoma (NVG), P = 0.964; recurrent retinal detachment, P = 0.531; postoperative fibrovascular proliferation progression, P = 0.682 and reoperation, P = 0.955) between the two groups. There were no statistically significant differences in best-corrected visual acuity (BCVA) at each follow-up visit (P = 0.939, 0.669, 0.741 and 0.717, respectively) or in central retinal thickness (CRT) (P = 0.976, 0.699, 0.551 and 0.686, respectively). As for safety profile, both groups had no ocular or system adverse events during the observation period. Conclusions IVR and IVC as a pretreatment of vitrectomy had similar efficacy and safety profile for Chinese PDR patients. Trial registration: Registered at ClinicalTrials.gov (NCT05414149).
Coordination compounds have undergone booming development in the past 20 years for their applications as multifunctional materials in the field of catalysis and biomedicine. To create compounds with both catalytic and bioactive properties, we selected Cu(II) ion and benzimidazole (Hbim) ligand as the building blocks to fabricate a new cluster-based Cu(II) compound [Cu4OCl6(Hbim)4]n·n(H2O)·2n(EtOH) (1). The exploration of single crystal X-ray diffraction exhibits that complex 1 is a 0D isolated structure on the basis of tetrahedral {Cu4O} clusters. Moreover, such supramolecular framework not only shows excellent photocatalytic effect for the MB photodegradation under the irradiation of ultraviolet light but also has the application values against orbital wall fracture. This work gives new insights on the creation of coordination polymers which might be potentially used as photocatalytic and bioactive reagents.
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