Two new half-sandwich cyclopentadienyl ruthenium(II) complexes containing a-amino acids, [CpRu-(PPh 3 ) 2 (Ser)] (Ser = L-serine) and [CpRu(PPh 3 )(Met)] (Met = L-methionine), were synthesized and characterized by physicochemical methods. Interactions of these two complexes with calf thymus DNA were investigated by UV-Vis absorption spectroscopy, emission spectroscopy and competitive binding studies. The results indicate that both complexes can interact with DNA, leading to the damage of the double helix. [CpRu(PPh 3 ) 2 (Ser)] binds to DNA by intercalation, while the binding mode for [CpRu(PPh 3 )(Met)] is more complicated due to the formation of an EB-DNA-complex (EB = ethidium bromide). The affinity of the Met complex for DNA is stronger than that of the Ser complex, which could be due to groove-surface combination or electrostatic interaction in addition to intercalative binding.
The interaction of [Ag(PPh 3 ) 2 (CH 3 COO)] (1) with thymine led to the displacement of the acetate ligand forming the mononuclear compound [Ag(PPh 3 ) 2 (C 5 H 5 N 2 O 2 )] (2). This compound has been characterized by IR, NMR, element analysis, and X-ray crystallographic analysis. Crystal structure of 2 shows each Ag ion is three-coordinated by two P atoms of the triphenylphosphino ligands and one N atoms of the thymine, which is stabilized by two intermolecular N-H. . .O and O-H. . .O hydrogen bonding interactions.
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