This work aimed to investigate the effect of magnetic Fe 3 O 4 nanoparticles (MNP), which are known to have a wide range of applications in recent years, on nanocomposite films prepared with shape memory polymers. Herein, PLA–PEG blend nanocomposite films were prepared by solution casting method using MNP at different ratios. PLA–PEG Blend/MNP nanocomposite films were characterized with Attenuated total reflection infrared spectroscopy (ATR-IR) to determine the –C=O stretching of PLA and Fe–O stretching signals of Fe 3 O 4 . The thermal stability, morphology, and magnetic behavior were studied by comparing the results among PLA–PEG blend, PLA–PEG blend/MNP nanocomposite with thermogravimetric analyses (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and a vibrating sample magnetometer (VSM), respectively. The effect of MNP on the shape memory properties of PLA/PEG blend was investigated. Moreover, the comparison of antimicrobial activity between PLA/PEG blend and PLA–PEG blend/MNP nanocomposite films were conducted by the disk diffusion method. The results showed that MNP increased the thermal stability of the PLA/PEG blend and the nanocomposites inhibited the growth of C.albicans microorganism. Graphical Abstract

This study was designed to synthesize poly(sodium acrylate-co-N-isopropylacrylamide) via aqueous free-radical polymerization using the 2,2′-azobisisobutyronitrile initiator system at 60°C. The structural characterization of the copolymer was determined by Fourier-transform infrared spectroscopy. The polymer was synthesized in two different ratios, namely, poly(NaAc-co-NIPA1:1) and poly(NaAc-co-NIPA2:1), to investigate whether it affects their antibacterial–antifungal activities and anti-tumour effects. When the antimicrobial activities of different proportions of the copolymer extracts prepared with pure water were examined using the agar disc diffusion sensitivity test (at 120 μL: 10.8 mg/µL), it was observed that they had effect at increasing rates against all the bacteria, yeasts and dermatophyte fungi such as Staphylococcus aureus COWAN 1, Staphylococcus cohnii ATCC 29974, Bacillus megaterium DSM 32, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae FMC 5, Pseudomonas aeruginosa DMS 50071 SCOTTA, Candida albicans FMC 17, Candida glabrata ATCC 66032, Trichophyton sp. and Epidermophyton sp. The results of this study revealed that the obtained copolymers have significant effects on the treatment of diseases. In addition, the anti-tumour activities of the poly(NaAc-co-NIPA1:1) copolymer on human breast (MCF-7) and ovarian cancer (A-2780) cell line were specified and it was determined that high doses of the copolymer showed anti-tumour effects on both types of cancer cell lines. Also, this article reviews its antimicrobial and anticancer activities that will be of help for future scientists.

This work researched the inhibitory properties of the extract of Phlomis rigida Labill plant including chloroform on gram-negative and positive bacteria, yeasts and dermatophyta; the related plant is used for therapeutic purpose in public. For the disk diffusion method, this extract is effective on Pseudomonas aeruginosa that is one of the negative bacterias by 11.33 ± 0.57 mm inhibition areas. Regarding other bacterias, the effect of the related extract is so low in avoiding the improvement of Escherichia coli, Staphylococcus aureus and Bacillus megaterium by 8.33 ± 0.57 mm inhibition area. It has highly effective on Trichopyton sp. and Candida albicans that are from dermatophytes fungis and yeast by 16.33 ± 0.57 mm inhibition area. About yeast and dermatophytes fungi it has a remarkable impact on Candida glabrata (14.33 ± 0.57 mm inhibition area), Epidermophyton sp. (12.33 ± 0.57 mm inhibition area). Antimicrobial activity of this natural extract against all the microorganisms that were tested by MIC method by concentrations vary by 100 uL and 6.25 uL. Acording to this; the results showed good inhibitory effect with 6.25 μL for C. albicans, Trichophyton sp. with 12.25 μL for C. glabrata.In the other hand it is effective with 25 μL for P. aeruginosa, Epidermophyton sp. with 50 μL for E. coli, S. aureus, B. megaterium. Being used plants for medical purposes as from since the early ages show that these plants can be used as alternatives of available antibiotics; including important medical components is the other reason for being an alternative at the same time. Concerning results, P. rigida can be utilized as a therapeutic drug for the healing of infections caused by microorganisms. In this study, we believe that the P. rigida is important in the search for new antibiotics and will contribute to the literature and the world of drug as it affects different types of microorganisms at the lowest level for the first time.

The aim of current study is to show phenolics, antioxidant capacities and antimicrobial activities of seeds of five Salvia L. (S. frigida Boiss., S. candidissima subsp. candidissima Vahl., S. virgata Jacq., S. verticillata L. var. verticillata and S. russellii Benth.) taxa grown in Turkey. The flavonoid and phenolic acid contents were measured by using HPLC whilst the antioxidant capacities were determined by using different methods. In addition, agar well diffusion method was used to determine the antimicrobial activities of Salvia species in this study. It was found that S. frigida, S. verticillata var. verticillata and S. russellii have the highest catechin contents and S. frigida and S. verticillata var. verticillata have high rosmarinic acid while S. frigida, S. candidissima subsp. candidissima and S. verticillata var. verticillata have high vanilic acid. Also, it was determined that S. frigida and S. verticillata var. verticillata have high DPPH radical scavenging activities in 150 and 250 µL while S. frigida and S. verticillata var. verticillata have highest ABTS radical scavenging activity in all concentrations apart from 25 µL for S. frigida. Furthermore, S. frigida and S. verticillata var. verticillata have high total phenolic contents. On the other hand, Salvia species have similar lipid peroxidation inhibitions. However, the metal chelating activities of Salvia species are different. And also, it was demonstrated that Salvia taxa have antimicrobial activity.

In this study, it was was researched the inhibitor effects of solutions including dichloromethane of poly dimethylacrylamide-co-methylmethacrylate P(DMAA-co-MMA) on microorganisms such as bacteria, yeast and dermatophyte fungi which cause serious illnesses in people. This solution, which was examined by the disc diffusion method, has antimicrobial feature upon preventing the proliferation of all bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) and dermatophyte fungi except Bacillus megaterium and Klebsiella pneumoniae. In antimicrobial susceptibility data; poly P(DMAA-co-MMA) dissolved in dichloromethane has an inhibitory effect against the growth of yeast and dermatophyte fungi (on Candida spp. with 11.3 mm / inhibition area -12.3 mm / inhibition area and 11.3 mm / inhibition area on Epidermophyton sp. -11.3 mm / inhibition area on Trichophyton sp.) (P <0.001). MIC (Minimal inhibition concentration) breakpoints that strengthen the disk diffusion method are 50-100 μL (4500-9000 µg in 10 mL) as the smallest value that inhibits the growth of bacteria, yeasts, dermatophyta. The antimicrobial compound can be of great advantage to illuminate future studies in this area. The polymer used in the study will provide a promising new addition to antimicrobial polymers that fight microorganisms that cause inflammation and fungal infections. www.dergipark.gov.tr/tdfd