The amino acid sequence of a cathepsm D mhibitor tsolated from potato is describedIt was determmed by analysis of peptides generated by use of the glycine-spectfic proteinase PPIV. The order of the peptides was established by exammation of tryptic peptides derived from the two cyanogen bromide peptides The Inhibitor comprises 187 ammo acid restdues. and has a calculated M, of 20 450Aspartic protemase mhtbitor, Ammo acid sequence: Cathepsm D
Cloning and characterization of three cDNAs and one gene coding for the aspartic proteinase inhibitor homologues, detection of four protein isoforms and analysis of the gene copy number indicate that in potato aspartic proteinase inhibitors are encoded by a multigene family.
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