The design and development of a mesoscale flow reactor is presented, together with initial performance evaluation. The custom-designed KRAIC (kinetically regulated automated input crystallizer) uses liquid-segmented flow to achieve plug flow and mixing throughout the reactor length while helping prevent encrustation issues experienced by other precipitation reactors and crystallizers. Evaluation of the reactor for production of solid-state particle products has been carried out using cooling crystallization of fast growing succinic acid to explore the potential of the KRAIC design to mediate blocking caused during the precipitation process. The segmented flow environment is successful in preventing encrustation during an unseeded 2 h cooling crystallization experiment.

Understanding the transitions between polymorphs is essential in the development of strategies for manufacturing and maximizing the efficiency of pharmaceuticals. However, this can be extremely challenging: crystallization can be influenced by subtle changes in environment such as temperature and mixing intensity or even imperfections in the crystallizer walls. Here, we highlight the importance of in situ measurements in understanding crystallization mechanisms, where a segmented flow crystallizer was used to study the crystallization of the pharmaceuticals urea:barbituric acid (UBA) and carbamazepine (CBZ). The reactor provides highly reproducible reaction conditions, while in situ synchrotron powder X-ray diffraction (PXRD) enables us to monitor the evolution of this system. UBA has two polymorphs of almost equivalent free-energy and so is typically obtained as a polymorphic mixture. In situ PXRD uncovered a progression of polymorphs from UBA III to the thermodynamic polymorph UBA I, where different positions along the length of the tubular flow crystallizer correspond to different reaction times. Addition of UBA I seed crystals modified this pathway such that only UBA I was observed throughout, while transformation from UBA III into UBA I still occurred in the presence of UBA III seeds. Information regarding the mixing-dependent kinetics of the CBZ form II to III transformation was also uncovered in a series of seeded and unseeded flow crystallization runs, despite atypical habit expression. These results illustrate the importance of coupling controlled reaction environments with in situ XRD to study the phase relationships in polymorphic materials. ASSOCIATED CONTENT Supporting InformationDetailed information regarding the experimental set-up, methodology and supporting experimental results is supplied as a word document, and a video showing the unusual needle habit of CBZ form III is supplied as a mp4 file in the supporting information. This material is available free of charge via the Internet at http://pubs.acs.org