We report the case of a 57 year old woman who developed headache, nausea, palpitation, tachycardia and hypotensione 30 minutes after eating spoiled tuna. A detailed food history and clinical exclusion helped to confirm a suspected diagnosis of scombroid poisining. The sign, symptoms, pathophysiology and management of poisoning from spoiled scombroid fish are discussed. The patient doesn’t recovered in hospital, but she remained in Emergency Department for some hours under the medical observation; it was necessary for confirm the diagnosis and procure the therapy
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