Between 1961 and 1984, 91 patients underwent simultaneous triple valve replacement at the Mayo Clinic. Of the 273 prosthetic valves used, 77% were Starr-Edwards. Perioperative (30 day) mortality was 24% to 27% between 1962 and 1974 and 7% between 1975 and 1983 (p = .17 1, 130-137, 1985. OVER the past 10 years, reports from many centers have defined the early and late results of cardiac valve replacement for most categories of patients.'-9 The outcome of triple valve replacement (aortic, mitral, and tricuspid valve replacement) is less well defined, primarily because of the relatively small numbers of patients who have undergone the operation. With the trend toward conservative tricuspid valve surgery coupled with the development of more predictable methods of valve repair and the declining incidence of rheumatic heart disease in the United States, triple valve replacement is less frequently required than it was previously. Nonetheless, rheumatic heart disease with involvement of multiple valves remains a serious problem in many countries.'0 Accordingly, we report our experience in 91 consecutive patients with rheumatic heart disease who underwent simultaneous triple valve From the Mayo Clinic and Mayo Foundation, Rochester, MN.
We propose a VT risk stratification scheme using signal-averaged ECG parameters obtained from both individual lead and vector magnitude analysis. This allows definition of four categories of VT risk derived statistically from the study data. This definition is based on combined measures of sensitivity, specificity, and negative and positive predictive value.
This study evaluated the relation between patency of the infarct-related artery and the presence of late potentials on the signal-averaged electrocardiogram (ECG) in 124 consecutive patients (98 men, 26 women; mean age 59 years) with acute myocardial infarction receiving thrombolytic therapy, acute percutaneous transluminal coronary angioplasty or standard care. All patients were studied by coronary angiography, measurement of ejection fraction and signal-averaged ECG. The infarct-related artery was closed in 51 patients and open in 73. Among patients with no prior myocardial infarction undergoing early attempted reperfusion therapy, a patent artery was associated with a decreased incidence of late potentials (20% versus 71%; no significant difference in ejection fraction). In the 48 patients receiving thrombolytic agents within 4 h of symptom onset, the incidence of late potentials was 24% and 83% among patients with an open or closed artery, respectively (p less than 0.04). The most powerful predictors of late potentials were the presence of a closed infarct-related artery, followed by prior infarction and patient age. Among patients receiving thrombolytic agents within 4 h of symptom onset, the only variable that was predictive of the presence of late potentials was a closed infarct-related artery. These data imply that reperfusion of an infarct-related artery has a beneficial effect on the electrophysiologic substrate for serious ventricular arrhythmias that is independent of change in left ventricular ejection fraction as an index of infarct size. These findings might explain, in part, the low late mortality rate in survivors of myocardial infarction with documented reperfusion of the infarct-related artery.
The most common arrhythmias associated with inferior-wall and anterior-wall myocardial infarction are bradycardia and supraventricular and ventricular tachycardia. Optimal treatment approaches are based on the pathophysiology of the infarct and the presence of contributing medical factors (eg, congestive heart failure, metabolic disorders). Temporary or permanent pacemaker therapy is helpful in some patients. Sudden death due to arrhythmia after myocardial infarction may be predicted and avoided in certain situations.
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