PurposeTo evaluate the feasibility of acute and chronic toxicity in patients suitable for accelerated partial breast irradiation (APBI) in a single 18 Gy fraction with multicatheter high-dose-rate (HDR) brachytherapy, as well as cosmetic and oncological outcomes.Material and methodsBetween September 2014 and March 2016, twenty consecutive patients with low-risk invasive and ductal carcinoma in situ were treated with interstitial multicatheter HDR brachytherapy in a single 18 Gy fraction.ResultsMedian age was 63.5 years (range, 51-79). Acute toxicity was observed in seven patients, while the pain during following days and hematoma were seen in four patients. With a median follow-up of 24 months, late toxicity was found in one patient with fat necrosis g2 and fibrosis g2 in another patient. The overall survival (OS) and locoregional control (LC) was 100%. Disease-free survival (DFS) and distant control was 95%. Good to excellent cosmetic outcomes were noted in 80% of patients and fair in 4 patients (20%).ConclusionsThis is the first report in the medical literature that focuses on feasibility and acute and chronic toxicity, with a median follow-up of 24 months (range, 20-40). The protocol is viable and convenient. However, a longer follow-up is needed to know chronic toxicity and oncologic outcomes.
Although clinical response is equal in both arms, overall survival (Cox) is better in the UFTVP arm. Febrile neutropenia and anaemia were more frequent with UFTVP while mucositis and trombocytopenia were more severe with PF.
Objective : To aim of the study is to determine the efficacy and safety of treatment with low-dose 3D external beam radiotherapy (EBRT) in patients with inguinal lymphorrhea. Material and methods : We retrospectively analyzed a total of 53 patients with persistent lymphorrhea after conservative treatment between 2008 and 2018. All patients were treated with 3D EBRT with photons of 6 - 18 MeV. The most common schedules were 7.5 Gy in 5 fractions (90.7%). Results : The complete closure of the fistula was achieved in 100% (43/43) of the patients. Three patients required re-irradiation due to persistence. We did not find any acute toxicity. Conclusions : Low-dose radiation therapy is effective and safe for treating persistent lymphorrheas.
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