Cervical aortic arch is rare with a prevalence of less than 1/10000 live births (Pediatr Cardiol 10 (1989) 205); but may occur with other cardiovascular congenital abnormalities. We report pseudocoarctation of a left-sided cervical aortic arch with an aberrant right subclavian artery and aortic and mitral regurgitation, corrected by an anterior mediastinal shunt from ascending to descending aorta and aortic and mitral valve replacements, as a one-stage procedure.
site reduced the leakage of albumin induced by BK+PGE2 from 5 3 B to 44% and 4633 fl and similarly HA+FGE2 was sugpressed from 54i12 to 34i8 and 4 1 i l l fl (all pcO.05) rpspeCtively.In addition, local blood flow changes were measured with a laser doppler in &bit dorsal skin mirocirculation (Warren et at. FASEB J. 1995; 9 41 1) to invesligate the blood flow changes caused by local injection of nifedipine lo".' or isoprpnalie 10'" moles per site. Niied, isoprenaline, and the two agenu together winjcaed, increased basal blood flow by 32i8, 68fl1, and 74i13% respeaiVely ( n 4 ) at I5 min. This indicates that i,soprenaline suppresses the formation of oedema despite haeasing blood flow. It probably acts to increase intraendothelial cell CAMP to relay contractile elements to tighten intercellular junctions.These fidings highlight the importance of microvascular phannawlogy in explaining the modulation of &ma by cardiovascular drugs. This work was supported by the British Hean Foundation.
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