Only limited data are available concerning the long-term outcomes of imatinib treatment among Vietnamese or Asian patients with unresectable or recurrent gastrointestinal stromal tumors (GISTs). Our study, which was conducted in 188 patients, aimed to assess the efficacy of imatinib mesylate against unresectable or recurrent GISTs. Imatinib had a high response rate and long survival. Some predictors favorable for progression-free survival and overall survival are good performance status and response with imatinib. Findings are discussed in relation to clinical practice in low- and middle-income country.
BRAF mutations are uncommon in non‐small cell lung cancer (NSCLC), accounting for less than 5% of all NSCLC cases. The utilization of targeted therapies in non‐V600E BRAF mutant NSCLC is considered controversial, although non‐V600E genotype is reported in ~50% of all BRAF mutant patients. We document the case of a 63‐year‐old patient with NSCLC harbouring a rare BRAF E501Q mutation, who had prolonged response to immunotherapy combined with chemotherapy in Vietnam. The patient was diagnosed with metastatic PD‐L1‐negative lung adenocarcinoma and received pembrolizumab plus chemotherapy as first‐line treatment. After completing 35 cycles of pembrolizumab and pemetrexed, his disease has remained stable during the treatment‐free follow‐up period, and he is alive 38 months after treatment initiation at the latest follow‐up. Immune‐based therapy is an appropriate option for lung adenocarcinoma with rare non‐V600E BRAF mutation. Further clinical studies are necessary to determine the effectiveness of using immune‐based therapy in this specific population.
Background: The nutritional status of the elderly is important but not being considered properly. This study aimed to assess the nutritional status and understand the eating habits of the elderly from some communes in Hue city as well as to study the relationship between nutritional status and eating habits of the study subjects. Materials and methods: A cross-sectional descriptive study was conducted by interviewing 408 people aged 60 and over who were living in Hue city using a pre-prepared questionnaire and MNA scale. Results: The prevalence of the elderly who were at risk of undernutrition and undernutrition were 33.8% and 2.2%, respectively. The age group with the highest risk of undernutrition was 60-74 years old (30.8%). Most of the subjects had a habit of stir-fry processing (24.5%) and boiled/steamed/water-bathed their food (24.2%). Most of the elderly used vegetable oil for processing and cooking (98.5%). The percentage of the elderly who used frying oil/fat many times accounted for 39.4%. There was 26.5% of the elderly used herbs and 25.5% of them used salty spices. 97.5% of the elderly did not use a spice measuring device when cooking. Most of them using food that was being tasted by the cook (84.9%). Only 25.7% of the elderly had the habit of reading food labels in which only 11.5% reading nutritional information. The percentage of the elderly who ate enough three primary meals/day was 94.1%; 14.5% of families have menus for the elderly; 53.9% of the elderly consumed more than 1500 ml fluids per day. The percentage of the elderly who ate fruit daily, had an average amount of vegetables > 300 g per day and used milk and dairy products every day were 7.6%, 21.6% and 41.7%, respectively. Some factors significantly related to nutritional status (p < 0.05) were eating under 3 primary meals per day, consuming ≤ 1500 ml of fluids per day, the family did not have a separated menu for the elderly. Conclusion: The prevalence of the elderly who were at risk of undernutrition and undernutrition in Hue city is quite high (36%). It is necessary to guide the elderly to have age-appropriate eating habits to ensure health.
Key words: Nutritional status, the elderly, eating habits, MNA
Đọc hiểu văn học nước ngoài là một trong những năng lực quan trọng cần hình thành và phát triển cho sinh viên ngành Sư phạm Ngữ văn. Trên cơ sở lí luận và thực tiễn, nghiên cứu này đề xuất một số giải pháp để phát triển năng lực đọc hiểu văn học nước ngoài cho sinh viên khoa Sư phạm Ngữ văn, Trường Đại học Đồng Tháp, nhằm đảm bảo chuẩn đầu ra, đáp ứng yêu cầu cấp thiết của đổi mới giáo dục đại học và đổi mới giáo dục phổ thông hiện nay
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