We present a new
synthetic method for the bis(dimethyl)phosphines Me4PCP
(C6H4-2,6-(CH2P(CH3)2)2) and DMPE
((CH3)2PCH2CH2P(CH3)2) that starts from an aminophosphine,
Et2NPMe2. Two equivalents of Et2NPMe2 react with the corresponding bis(alkyl bromide) to afford
an oxygen- and moisture-stable aminophosphonium salt. NaAlH4 selectively reduces the aminophosphonium salt to the desired phosphine.
Each step is high yielding and requires minimal purification.
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