Background-Cancer immunotherapy involving NK-cell infusions and administration of therapeutic agents modulating the susceptibility of tumors to NK-cell lysis has been recently proposed. Here we provide a method to expand highly cytotoxic clinical grade NK cells in vitro for adoptive transfer following bortezomib treatment in patients with advanced malignancies.
Lung CFUs also were reduced to the same extent in vaccinated Il18r-/and wild-type mice (Supplemental Figure 7B). In contrast, IL-17-producing T cells recruited to the lungs of IL1r-/mice were reduced, and the mice failed to acquire resistance in comparison with vaccinated wild-type controls. Thus, IL-18R, but not IL-1R, is dispensable in the development of T17 cells and vaccine resistance. Moreover, failed T17 differentiation of 1807 cells in Myd88-/mice is not due to impaired IL-18R signaling, but is likely due to impaired signaling via TLRs and IL-1R. Discussion The fact that adoptively transferred wild-type 1807 cells failed to recruit to the lung in Myd88-/mice and showed a deficit in IL1r-/-, but not Il18r-/-, mice indicates that the deficits in Myd88-/mice are not due to impaired IL-18R signaling, but are likely due to impaired signaling via TLRs and IL-1R.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.