Studies have been conducted in a number of species to try to correlate tissue levels of reserpine with pharmacologic activity. Despite the fact that studies on the distribution, excretion, and metabolism of reserpine in the mouse, Because comparative studies of drug metabolism in several species are important in integrating knowledge of the biological handling of a drug, we are reporting the results of a study in man.Received for publication Dec. 19, 1968. Accepted for publication Feb. 19, 1969.
366Furthermore, because the size of the doses of reserpine used have changed over the years, a more representative pharmacologic dose to obtain data on absorption, excretion, and metabolism should be used.
MethodsReserpine,"' tritiated in the 2 and 6 position of the trimethoxybenzoyl ring, was purified by column chromatography and recrystallization. This material, chromatographed on alumina with the use of a chloroform: acetone ( 85: 15) system was found to be 99 per cent pure, based on both•Purchased from the New England Nuclear Corporation.
Tablets and capsules of a combination product containing triamterene and hydrochlorothiazide in a 2:1 ratio were compared in a series of short‐term studies with male volunteers. The tablet caused approximately twice as much excretion of hydrochlorothiazide and 3 times as much triamterene as the capsule. These studies provide further evidence of the importance of the dosage forms in the effectiveness of drugs.
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