IT administration of methylprednisolone in humans results in much higher perilymph concentrations and much lower systemic concentrations than IV administration.
Administration of dexamethasone IT results in much higher perilymph concentrations and much lower plasma concentrations compared with IV administration.
This canal wall up procedure allows long electrode insertion without radical cavity/obliteration in patients with fully ossified cochleas and prevents distraction of the electrode from the cochlea. While open-set word recognition was achieved by all subjects, results are poorer than expected for patients with limited or no ossification.
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