Linear frequency transposition improved fricative identification over time. Proper candidate selection with appropriate training is necessary to fully realize the potential benefit of this type of processing.

Background: Detection of myocardial ischemia was studied with multichannel exercise magnetocardiography (MCG). A surface gradient method was applied to analyze cardiac magnetic fields.Methods: We studied 27 patients with single vessel coronary artery disease (CAD) and 17 healthy volunteers. The MCG was recorded over anterior chest during supine bicycle ergometry. The two-dimensional direction of the maximum spatial magnetic field gradient was determined during the ST segment and at the T-wave apex at different phases of stress test.Results: The CAD patient group was separated from controls by the orientation of the magnetic field gradient during the ST segment at cessation of exercise (CAD 167 ? 68" vs controls 106 ? 49"; P < 0.005) and at 4 minutes postexercise, but not at rest. The CAD patient group was separated from controls also by the orientation of the magnetic field gradient at the T-wave apex at 4 minutes postexercise (CAD 87 ? 60" vs controls 58 +-18"; P < 0.05), but not at rest. The change in the orientation of the field gradient at the T-wave apex 4 minutes postexercise, compared to baseline, was greater in CAD patients (31 +-43") than in controls (9 ? 8"; P < 0.05). This change was larger in the patient group with stenosis in the right than in the left coronary artery (P < 0.05).Conclusions: Transient acute myocardial ischemia causes well-recognizable changes in the magnetocardiogram at the ST segment and the T wave. The orientation of the maximum spatial gradient of the magnetic field can be used as a parameter to determine these changes.

Late fields of the MCG QRS complex indicate propensity to life-threatening arrhythmias in post-MI patients. This discriminative ability persists in the presence of severe left ventricular dysfunction where ECG late potentials lose their informative value. MCG late field analysis is a potential new method for noninvasive risk assessment in post-MI patients.

Increased QRS fragmentation in post-MI patients predicts cardiac deaths and HF progression. A computer-based fragmentation analysis is a stronger predictor than QRSd.

Depressive symptoms are common in hypertensive persons even without comorbidities, if the person is already aware of his/her hypertension. Many modifiable, lifestyle associated factors may contribute to the association of hypertension and depressive symptoms. Key Points Hypertension and depressive symptoms are known to form a toxic combination contributing even to all-cause mortality. Comorbidities or the labelling effect of the diagnosis of hypertension can confound their association. Our study shows that depressive symptoms are common in hypertensive persons even without comorbidities, if the person is already aware of his/her hypertension. Many modifiable, lifestyle-associated factors may contribute to the association of hypertension and depressive symptoms. When treating hypertensive patients, consideration of depressive symptoms is important in order to promote favorable lifestyle and control of hypertension.

This study identified magnetocardiographic and BSPM recording locations which are sensitive for detecting transient myocardial ischemia by evaluation of the ST segment as well as the T-wave. These locations strongly depend on ischemic regions and are outside the conventional 12-lead ECG recording sites.

Aims and objectives To describe advance care planning (ACP) for patients with cancer in palliative care from professionals' perspective. Background The number of patients with cancer is increasing. Palliative care should be based on timely ACP so that patients receive the care they prefer. Design A scoping review. Methods A systematic literature search was conducted in January 2019. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) checklist was used. The methodological quality of the studies was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal tools. Data were analysed with content analysis. Results Of 739 studies identified, 12 were eligible for inclusion. The settings were inpatient and outpatient facilities in special and primary care including oncology, palliative and hospice care. ACP consisted of patient‐oriented issues, current and future treatment, and end‐of‐life matters. The participants were nursing, medical or social professionals. ACP conversations rarely occurred; if they did, they took place at the onset, throughout and late in the cancer. Conclusions Professionals could not separate day‐to‐day care planning and ACP. ACP documentation was scattered and difficult to find and use. Professionals were unfamiliar with ACP, and established practices were lacking. ACP conversations mostly occurred in late cancer. Further research clarifying concepts and exploring the significance of ACP for patients and relatives is recommended. Relevance to clinical practice Our results support the use of ACP by a multidisciplinary team from the early stages of cancer as a discussion forum around patients' wishes and choices. We showed the need to raise professionals' awareness of ACP. Education and appropriate data tools for ACP are important as they may reduce reluctance and promote ACP use. This paper contributes to the wider global clinical community by pointing out the importance of standardising ACP contents and practices.

In post-MI patients with left ventricular dysfunction, increased intra-QRS fragmentation in high-resolution magnetocardiography predicts arrhythmic events, whereas QRS duration in 12-lead ECG predicts all-cause mortality. Analysis of intra-QRS fragmentation by MCG may assist in guiding therapy of post-MI patients, for example, by selecting those who would benefit most from prophylactic implantable cardioverter-defibrillator therapy.