The adoption of permissioned blockchain networks in enterprise settings has seen an increase in growth over the past few years. While encouraging, this is leading to the emergence of new data, asset and process silos limiting the potential value these networks bring to the broader ecosystem. Mechanisms for enabling network interoperability help preserve the benefits of independent sovereign networks, while allowing for the transfer or sharing of data, assets and processes across network boundaries. However, a naive approach to interoperability based on traditional point-to-point integration is insufficient for preserving the underlying trust decentralized networks provide. In this paper, we lay the foundation for an approach to interoperability based on a communication protocol that derives trust from the underlying network consensus protocol. We present an architecture and a set of building blocks that can be adapted for use in a range of network implementations and demonstrate a proof-of-concept for trusted data-sharing between two independent trade finance and supply-chain networks, each running on Hyperledger Fabric. We show how existing blockchain deployments can be adapted for interoperation and discuss the security and extensibility of our architecture and mechanisms.
Background: Timely sharing of electronic health records across providers, while ensuring data security and privacy, is essential for prompt care of cancer patients, as well as for the development of medical research and the enhancement of personalized medicine. Yet, it is not trivial to achieve efficient consent management, data exchange, and access-control policy enforcement, in particular, in decentralized settings, and given the gravity of the condition such as cancer. Using blockchain technology (BCT) has been recently advocated by research communities and gained momentum from the industry perspective. However, most of the proposed solutions are at the level of a prototype, and blockchain-based healthcare data management systems are not in place yet. Summary: This paper presents a systematic literature review, aiming to analyze the motivations, advantages, and limitations, as well as barriers and future challenges faced when applying the state-of-the-art distributed ledger technology in oncology. We then discuss its outcomes and propose the direction of the future research that can help to attain integration and adoption of the BCT for data-sharing, medical research, and the pharmaceutical supply chain in oncology, as well as in healthcare in general. Key Messages: BCT has the potential to enhance data-sharing (for primary care and medical research), as well as to attain optimization of the pharmaceutical supply chain by bringing properties such as transparency, traceability, and immutability to the applications. However, BCT itself cannot guarantee data privacy and security. Thus, it is never proposed as a stand-alone technology, but as a combined technology with cryptographic techniques. Regardless of the number of existing prototypes of blockchain-based healthcare systems, due to the existing barriers of the adoption (e.g., legal, social, and technological limitations), there is a lack of evaluation in realworld settings. Aiming to overcome these limitations, we propose future research directions that include design of the privacy-preserving hybrid data storage, interoperable infrastructures and architecture, and are compliant with the international laws and regulations.
Academic publishing is continuously evolving with the gradual adoption of new technologies. Blockchain is a new technology that promises to change how individuals and organizations interact across various boundaries. The adoption of blockchains is beginning to transform diverse industries such as finance, supply chain, international trade, as well as energy and resource management and many others. Through trust, data immutability, decentralized distribution of data, and facilitation of collaboration without the need for centralized management and authority, blockchains have the potential to transform the academic publishing domain and to address some of the current problems such as productivity and reputation management, predatory publishing, transparent peer-review processes and many others. In this paper, we outline the technologies available in the domain of permissioned blockchains with focus on Hyperledger Fabric and discuss how they can be leveraged in the domain of academic publishing.
The rise of crypto-currencies has spawned great interest in their underlying technology, namely, Blockchain. The central component in a Blockchain is a shared distributed ledger. A ledger comprises series of blocks, which in turns contains a series of transactions. An identical copy of the ledger is stored on all nodes in a blockchain network. Maintaining ledger integrity and security is one of the crucial design aspects of any blockchain platform. Thus, there are typically built-in validation mechanisms leveraging cryptography to ensure the validity of incoming blocks before committing them into the ledger. However, a blockchain node may run over an extended period of time, during which the blocks on the disk can may become corrupted due to software or hardware failures, or due to malicious activity. This paper proposes LedgerGuard, a tool to maintain ledger integrity by detecting corrupted blocks and recovering these blocks by synchronizing with rest of the network. The experimental implementation of LedgerGuard is based on Hyperledger Fabric, which is a popular open source permissioned blockchain platform.
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