Norway spruce (Picea abies [L.] Karst.) and silver fir (Abies alba Mill.) are main tree species of Central Europe that are currently highly vulnerable in times of global climate change. The research deals with the effect of climate and air pollution on radial growth of silver fir and Norway spruce in mixed age-varied (56 – 146 years) forests in the Jeseníky Protected Landscape Area, the Czech Republic. The objectives were to evaluate biodiversity, structure and production, specifically interaction of radial growth of fir and spruce to air pollution (SO2, NOX, tropospheric ozone) and climatic factors (precipitation, air temperature). Concentration of SO2 and NOX had negative effect on radial growth of fir, while radial growth of spruce was more negatively influenced by tropospheric ozone. Fir showed higher variability in radial growth and was more sensitive to climatic factors compared to spruce. On the other hand, fir was relatively adaptable tree species that regenerated very well when the pressure of stress factors subsided (air pollution load, Caucasian bark beetle, frost damage). Low temperature was a limiting factor of radial growth in the study mountainous area, especially for fir. Fir was significantly sensitive to late frost, respectively, spruce to winter desiccation and spring droughts with synergism of air pollution load. Generally, older forest stands were more negatively influenced by air pollution load and climatic extremes compared to young trees.