Supplementation with fermented milk, containing live special probiotic L. casei DN-114 001, confers an enhanced therapeutic benefit on H. pylori eradication in children with gastritis on triple therapy.

A sterol-polyether conjugate, 5-androstene3j3,17j3-bis[(oxycarbonyl)hexaethylene glycol] (l), has been synthesized via condensation of the bis-chloroformate derivative of 5-androstene-3j3,17j3-diol with hexaethylene glycol mono(triphenylmethy1 ether), followed by deprotection. This conjugate, which is composed of a long and rigid hydrophobic unit, two flexible hydrophilic chains that are linked to the hydrophobic unit, and a pendant polar head group, was designed as a prototype for new classes of compounds that are intended to serve as functional equivalents of the polyene macrolide antibiotic amphotericin B. Analysis of the surface pressurearea isotherm of 1, generated at the air-water interface, indicates a limiting area of ca. 60 A2 per molecule. This value is fully consistent with a model in which the sterol nucleus (ca. 40 A2) and one pendant polyether chain (ca. 20 A2) define the collisional area of the surfactant; that is, it supports the existence of a 'folded" conformation at the air-water interface. Incorporation of 1 into egg PC vesicular membranes leads to ion channel formation, as demonstrated by 23Na NMR spectroscopy. Operationally, 1 has been found to have an ionophoric activity that is very similar to that found for a synthetic "bouquet" molecule, but significantly less than amphotericin B, itself.

This study confirmed an increase in incidence of CD in children younger than 15 years in the Czech Republic.

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The time to steady state of 6-TGN erythrocyte concentration is significantly shorter than would expected according to clinical observation describe earlier.

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The aim of this study is to report our 3years experience with the screening of congenital disorders of glycosylation. A common isoelectric focusing method with immunofixation was used for analysis of serum transferrin and α1-antitrypsin, apart from several other procedures. A group of about 1000 individuals, both healthy controls and patients, mostly with signs of a metabolic disease were examined. Here we present an overview of 1) hypoglycosylation findings, 2) distribution of protein variants, 3) misguiding rare Tf variants found in our set, and 4) association of some phenotypes with various diseases.