The use of di-isopropyl phenol (Diprivan) for induction of anaesthesia was assessed in doses ranging from 1 to 3 mg kg-1. With less than 1.75mg kg-1 not all patients were anaesthetized; 2.0 mg kg-1 appeared to be a satisfactory induction dose. Involuntary muscle movement, cough and hiccup at induction were rare with any dose studied. However, the frequency of hypotension and respiratory depression were related to the dose given. Pain on injection was uncommon when the drug was given into an antecubital vein, but occurred in 39% of patients when injected to the back of the hand or wrist. Recovery was rapid, and characterized by lack of emetic sequelae. Di-isopropyl phenol 1.5 - 2.0 mg kg-1 given rapidly during reactive hyperaemia can produce anaesthesia in one arm-brain circulation time. A reaction involving flush, hypotension, cough, laryngospasm and bronchospasm occurred in one patient receiving 2.5 mg kg-1 given over 20 s.
Fifty women aged 70 years and older with newly diagnosed carcinoma of the breast were prospectively studied after being offered a choice of four treatment options. Thirty-four of 38 patients who chose their own treatment had breast conservation; four opted for mastectomy. At 12-month follow-up only two women were unhappy with their choice of treatment. It is concluded that elderly women should be involved in deciding the treatment of their breast cancer.
A trial strain-monitoring system using Brillouin optical time-domain reflectometry (BOTDR) technology was set up to monitor joint movements in the concrete tunnel lining in an existing London Underground tunnel. The BOTDR strain sensor system allows the measurement of strain distribution along an optical fibre using the reflective technique, requiring access to only one end of the fibre. Measurements were obtained by a strain-sensing optical fibre installed along the tunnel lining. The joint movements were captured by measuring the strain along the fibre across the segment joints. The results show that there is good agreement between the joint movements evaluated by the BOTDR strain sensor system and those by conventional vibrating-wire strain gauges. Whereas conventional strain measurement gauges monitor the strain variations at discrete locations, a BOTDR strain sensor can provide a continuous strain distribution of the tunnel lining. The results demonstrate the practicality of using the BOTDR strain-sensing system to monitor the movement of tunnel linings.
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