The gastrointestinal tract (GIT) represents the largest interface between the human organism and the external environment. In the lumen and upper part of the mucus layer, this organ hosts an enormous number of microorganisms whose composition affects the functions of the epithelial barrier and the gut immune system. Consequentially, the microorganisms in the GIT influence the health status of the organism. Probiotics are living microorganisms which, in specific conditions, confer a health benefit to the host. Among others, probiotics have immunomodulatory properties that usually act directly by (a) increasing the activity of macrophages or natural killer cells, (b) modulating the secretion of immunoglobulins or cytokines, or indirectly by (c) enhancing the gut epithelial barrier, (d) altering the mucus secretion, and (e) competitive exclusion of other (pathogenic) bacteria. This review focuses on specific bacteria strains with indirect immunomodulatory properties. Particularly, we describe here the mechanisms through which specific probiotics enhance the gut epithelial barrier and modulate mucus production. Moreover, we describe the antimicrobial properties of specific bacteria strains. Recent data suggest that multiple pathologies are associated with an unbalanced gut microflora (dysbiosis). Although the cause-effect relationship between pathology and gut microflora is not yet well established, consumption of specific probiotics may represent a powerful tool to re-establish gut homeostasis and promote gut health.

It has become increasingly evident in recent years that the gut microbiome and the brain communicate in a bidirectional manner, with each possibly affecting the other's functions. Substantial research has aimed to understand the mechanisms of this interaction and to outline strategies for preventing or treating nervous system-related disturbances. This review explores the evidence demonstrating how the gut microbiome may affect brain function in adults, thereby having an impact on stress, anxiety, depression, and cognition. In vitro, in vivo, and human studies reporting an association between a change in the gut microbiome and functional changes in the brain are highlighted, as are studies outlining the mechanisms by which the brain affects the microbiome and the gastrointestinal tract. Possible modes of action to explain how the gut microbiome and the brain functionally affect each other are proposed. Supplemental probiotics to combat brain-related dysfunction offer a promising approach, provided future research elucidates their mode of action and possible side effects. Further studies are warranted to establish how pre- and probiotic interventions may help to balance brain function in healthy and diseased individuals.

Aerodynamic theory predicts that dust grains in protoplanetary disks will drift radially inward on comparatively short timescales. In this context, it has long been known that the presence of a gap opened by a planet can alter the dust dynamics significantly. In this paper, we carry out a systematic study employing long-term numerical simulations aimed at characterizing the critical particle-size for retention outside a gap as a function of particle size and for various key parameters defining the protoplanetary disk model. To this end, we perform multifluid hydrodynamical simulations in two dimensions, including different dust species, which we treat as pressureless fluids. We initialize the dust outside of the planet's orbit and study under which conditions dust grains are able to cross the gap carved by the planet. In agreement with previous work, we find that the permeability of the gap depends both on dust dynamical properties and the gas disk structure: while small dust follows the viscously accreting gas through the gap, dust grains approaching a critical size are progressively filtered out. Moreover, we introduce and compute a depletion factor that enables us to quantify the way in which higher viscosity, smaller planet mass, or a more massive disk can shift this critical size to larger values. Our results indicate that gap-opening planets may act to deplete the inner reaches of protoplanetary disks of large dust grains -potentially limiting the accretion of solids onto forming terrestrial planets.

Jupiter and Saturn formed early, before the gas disk dispersed. The presence of gap-opening planets affects the dynamics of the gas and embedded solids and halts the inward drift of grains above a certain size. A drift barrier can explain the absence of calcium aluminium rich inclusions (CAIs) in chondrites originating from parent bodies that accreted in the inner solar system. Employing an interdisciplinary approach, we use a µ-X-Ray-fluorescence scanner to search for large CAIs and a scanning electron microscope to search for small CAIs in the ordinary chondrite NWA 5697. We carry out long-term, two-dimensional simulations including gas, dust, and planets to characterize the transport of grains within the viscous α-disk framework exploring the scenarios of a stand-alone Jupiter, Jupiter and Saturn in situ, or Jupiter and Saturn in a 3:2 resonance. In each case, we find a critical grain size above which drift is halted as a function of the physical conditions in the disk. From the laboratory search we find four CAIs with a largest size of ≈200 µm. Combining models and data, we provide an estimate for the upper limit of the α-viscosity and the surface density at the location of Jupiter, using reasonable assumptions about the stellar accretion rate during inward transport of CAIs, and assuming angular momentum transport to happen exclusively through viscous effects. Moreover, we find that the compound gap structure in the presence of Saturn in a 3:2 resonance favors inward transport of grains larger than CAIs currently detected in ordinary chondrites.

Encouraging scientific research into the health effects of dietary bioactive resveratrol has been confounded by its rapid first-pass metabolism, which leads to low in vivo bioavailability. Preliminary studies have shown that resveratrol can modulate gut microbiota composition, undergo biotransformation to active metabolites via the intestinal microbiota, or affect gut barrier function. In rodents, resveratrol can modify the relative Bacteroidetes:Firmicutes ratio and reverse the gut microbial dysbiosis caused by a high-fat diet. By upregulating the expression of genes involved in maintaining tight junctions between intestinal cells, resveratrol contributes to gut barrier integrity. The composition of the gut microbiome and rapid metabolism of resveratrol determines the production of resveratrol metabolites, which are found at greater concentrations in humans after ingestion than their parent molecule and can have similar biological effects. Resveratrol may affect cardiovascular risk factors such as elevated blood cholesterol or trimethylamine -oxide concentrations. Modulating the composition of the gut microbiota by resveratrol may affect central energy metabolism and modify concentrations of satiety hormones to produce antiobesity effects. Encouraging research from animal models could be tested in humans.

Context. High-resolution ALMA observations such as the DSHARP campaign have revealed a variety of rich substructures in numerous protoplanetary disks. These structures consist of rings, gaps, and asymmetric features. It has been debated whether planets can be accounted for among these substructures in the dust continuum. Characterizing the origin of asymmetries, as seen in HD 163296, might lead to a better understanding of planet formation and the underlying physical parameters of the system. Aims. We test the possibility that the formation of the crescent-shaped asymmetry in the HD 163296 disk can be attributed to planet-disk interaction. The goal is to obtain constraints on planet masses, eccentricities, and disk viscosities. Furthermore, we test the reproducibility of the two prominent rings in the HD 163296 disk at 67 and 100 au. Methods. We performed two-dimensional, multi-fluid, hydrodynamical simulations with the FARGO3D code, including three embedded planets in the setup. Dust is described via the pressureless fluid approach and distributed over eight size bins. The resulting grids were post-processed with the radiative transfer code RADMC-3D and CASA software to model the synthetic observations. Results. We find that the crescent-shaped asymmetry can be qualitatively modeled with a Jupiter mass planet at a radial distance of 48 au. Dust is trapped in the trailing Lagrange point L5, preferably, with a mass of between 10 and 15 earth masses. The observation of such a feature constrains the level of viscosity and planetary mass. Increased values of eccentricity of the innermost Jupiter mass planet negatively impacts the stability of the crescent-shaped feature and does not reproduce the observed radial proximity to the first prominent ring in the system. Generally, a low level of viscosity (α ≤ 2 × 10−3) is necessary to allow for the existence of such a feature. Including dust feedback in the leading point, L4, can dominantly capture dust for dust grains with an initial Stokes number ≤ 3.6 × 10−2. In the synthetic ALMA observation of the model with dust feedback, two crescent-shaped features are visible. The observational results suggest a negligible effect on the part of dust feedback since only one such feature has been detected so far. The dust-to-gas ratio may thus be overestimated in the models. Additionally, the planet mass growth time scale does not strongly affect the formation of such asymmetries in the co-orbital region.

Emerging evidence suggests that the gut microbiota has a critical role in both the maintenance of human health and the pathogenesis of many diseases. Modifying the colonic microbiota using functional foods has attracted significant research effort and product development. The pioneering concept of prebiotics, as introduced by Gibson and Roberfroid in the 1990s, emphasized the importance of diet in the modulation of the gut microbiota and its relationships to human health. Increasing knowledge of the intestinal microbiota now suggests a more comprehensive definition. This paper briefly reviews the basics of the prebiotic concept with a discussion of recent attempts to refine the concept to open the door for novel prebiotic food ingredients, such as polyphenols, minerals and vitamins.

The migration of planetary cores embedded in a protoplanetary disk is an important mechanism within planetformation theory, relevant for the architecture of planetary systems. Consequently, planet migration is actively discussed, yet often results of independent theoretical or numerical studies are unconstrained due to the lack of observational diagnostics designed in light of planet migration. In this work we follow the idea of inferring the migration behavior of embedded planets by means of the characteristic radial structures that they imprint in the disk's dust density distribution. We run hydrodynamical multifluid simulations of gas and several dust species in a locally isothermal α-disk in the low-viscosity regime (α = 10 −5 ) and investigate the obtained dust structures. In this framework, a planet of roughly Neptune mass can create three (or more) rings in which dust accumulates. We find that the relative spacing of these rings depends on the planet's migration speed and direction. By performing subsequent radiative transfer calculations and image synthesis we show that -always under the condition of a near-inviscid disk -different migration scenarios are, in principle, distinguishable by long-baseline, state-of-the-art ALMA observations.