The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

A B S T R A C T Mineralocorticoid-treated, normotensive third trimester subjects positioned in lateral recumbency were studied before and during the infusion of 300 mEq of hypotonic saline. Urinary sodium excretion increased in all subjects from a mean value of 199 to 416 IAEq/min.In 12 maximally hydrated subjects free water clearance (CH2o) and urine flow (V) increased from means of 7.54 and 9.50 to 11.6 and 14.5 ml/100 ml of glomerular filtrate (GFR) Also the ratio of urea to inulin clearance (Curen/Cinuiln) increased from 0.59 to 0.64. The changes in the renal handling of water and urea suggest that fractional sodium reabsorption decreased at proximal nephron sites.The subjects then assumed a supine position, and the results were compared to those obtained during the lateral recumbent control periods. Filtered sodium decreased in 11 experiments, but in five studies it remained up to 2.6 mEq/min above control values. There was only one instance in which a significant increase in sodium excretion occurred. It was concluded that supine recumbency blunts natriuresis despite volume expansion or an increase in the filtered load of sodium.Finally, in the 12 hydrated subjects supine recumbency reduced CH2o and V from a mean of 11.6 and 14.5 to 6.2 and 8.2 ml/100 ml of GFR. In eight of these experiPreliminary reports of this work have been published in abstract form:

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