The 2dF (Two‐degree Field) facility at the prime focus of the Anglo‐Australian Telescope provides multiple‐object spectroscopy over a 2° field of view. Up to 400 target fibres can be independently positioned by a complex robot. Two spectrographs provide spectra with resolutions of between 500 and 2000, over wavelength ranges of 440 and 110 nm respectively. The 2dF facility began routine observations in 1997. 2dF was designed primarily for galaxy redshift surveys and has a number of innovative features. The large corrector lens incorporates an atmospheric dispersion compensator, essential for wide wavelength coverage with small‐diameter fibres. The instrument has two full sets of fibres on separate field plates, so that re‐configuring can be done in parallel with observing. The robot positioner places one fibre every 6 s, to a precision of 0.3 arcsec (20 μm) over the full field. All components of 2dF, including the spectrographs, are mounted on a 5‐m diameter telescope top end ring for ease of handling and to keep the optical fibres short in order to maximize UV throughput. There is a pipeline data reduction system which allows each data set to be fully analysed while the next field is being observed. 2dF has achieved its initial astronomical goals. The redshift surveys obtain spectra at the rate of 2500 galaxies per night, yielding a total of about 200 000 objects in the first four years. Typically a B=19 galaxy gives a spectrum with a signal‐to‐noise ratio of better than 10 per pixel in less than an hour; redshifts are derived for about 95 per cent of all galaxies, with 99 per cent reliability or better. Total system throughput is about 5 per cent. The failure rate of the positioner and fibre system is about 1:10 000 moves or once every few nights, and recovery time is usually short. In this paper we provide the historical background to the 2dF facility, the design philosophy, a full technical description and a summary of the performance of the instrument. We also briefly review its scientific applications and possible future developments.

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For many respiratory pathogens, CD8؉ T cells have been shown to play a critical role in clearance. However, there are still many unanswered questions with regard to the factors that promote the most efficacious immune response and the potential for immunoregulation of effector cells at the local site of infection. We have used infection of the respiratory tract with the model paramyxovirus simian virus 5 (SV5) to study CD8 ؉ T-cell responses in the lung. For the present study, we report that over time a population of nonresponsive, virus-specific CD8 ؉ T cells emerged in the lung, culminating in a lack of function in ϳ85% of cells specific for the immunodominant epitope from the viral matrix (M) protein by day 40 postinfection. Concurrent with the induction of nonresponsiveness, virus-specific cells that retained function at later times postinfection exhibited an increased requirement for CD8 engagement. This change was coupled with a nearly complete loss of functional phosphoprotein-specific cells, a response previously shown to be almost exclusively CD8 independent. These studies add to the growing evidence for immune dysregulation following viral infection of the respiratory tract.

Weanling female and male rats were exposed to either pups or pup-sized toys for 10 days beginning at 22 days of age in order to assess differences between pup-directed and toy-directed behaviors and to determine whether exposure to pups at this time increases susceptibility to maternal sensitization in adulthood. Adult sensitization involved exposing each subject to pups for 10 days beginning at 78 days of age. The principal results were as follows: (a) Weanlings retrieved, licked, and lay over pups, but not toys, and chewed on toys, but not pups, (b) Weanling males snowed more pup retrieval than weanling females, (c) Females and males preexposed to pups during "weanlinghood" showed more retrieval and licking of pups in adulthood than those not preexposed to pups, (d) Adult females were more fully maternal or nonmaternal than were adult males or weanlings of either sex, as indicated by their lower "partial retrieval" and "inconsistent retrieval" scores, their tendency to retrieve rapidly or not at all, and their greater correlation between retrieval and nest construction.